Long‐pulsed neodymium:yttrium‐aluminum‐garnet laser treatment for hypertrophic port‐wine stains on the lips

Department of Plastic and Reconstructive Surgery, Tokyo Women's Medical University, Tokyo, Japan.
Journal of Cosmetic and Laser Therapy (Impact Factor: 1.11). 10/2008; 11(1):11-3. DOI: 10.1080/14764170802307940
Source: PubMed


Pulsed dye laser (PDL) treatment of hypertrophic port-wine stains (PWSs) on the lips has demonstrated poor efficacy and a potential risk of dyspigmentation. PDL-resistant hypertrophic PWS may require treatment with deeper penetrating lasers such as a 1064-nm neodymium:yttrium-aluminum-garnet (Nd:YAG) laser. The objective of this clinical study was to evaluate the efficacy and safety of a Nd:YAG laser for the treatment of hypertrophic PWSs on the lips. Ten patients (four were male and six were female) with hypertrophic PWSs on the lips were recruited in this study. Eight patients showed good to excellent improvement without complications. In conclusion, the Nd:YAG laser is safe and effective for treating hypertrophic PWSs on the lips.

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    • "Unfortunately, the clinical reality is that laser therapy is effective in approximately half of PWS patients (Fig. 1c).1,5,11,12,20,27,32,34,41,53,56–58,70,71,79,80,83,84,88,90,109,110,113,124,130,133,144,159,160 This overview therefore focuses on the causes of the therapeutic recalcitrance and presents several experimental engineering approaches, including (1) alterations in local hemodynamics, (2) concomitant laser treatment and dermo-vascular imaging, and (3) site-specific pharmaco-laser therapy, with which the therapeutic efficacy of recalcitrant PWSs may be improved. "
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