Long‐pulsed neodymium:yttrium‐aluminum‐garnet laser treatment for hypertrophic port‐wine stains on the lips
ABSTRACT Pulsed dye laser (PDL) treatment of hypertrophic port-wine stains (PWSs) on the lips has demonstrated poor efficacy and a potential risk of dyspigmentation. PDL-resistant hypertrophic PWS may require treatment with deeper penetrating lasers such as a 1064-nm neodymium:yttrium-aluminum-garnet (Nd:YAG) laser. The objective of this clinical study was to evaluate the efficacy and safety of a Nd:YAG laser for the treatment of hypertrophic PWSs on the lips. Ten patients (four were male and six were female) with hypertrophic PWSs on the lips were recruited in this study. Eight patients showed good to excellent improvement without complications. In conclusion, the Nd:YAG laser is safe and effective for treating hypertrophic PWSs on the lips.
- SourceAvailable from: Bernard Choi
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- "Unfortunately, the clinical reality is that laser therapy is effective in approximately half of PWS patients (Fig. 1c).1,5,11,12,20,27,32,34,41,53,56–58,70,71,79,80,83,84,88,90,109,110,113,124,130,133,144,159,160 This overview therefore focuses on the causes of the therapeutic recalcitrance and presents several experimental engineering approaches, including (1) alterations in local hemodynamics, (2) concomitant laser treatment and dermo-vascular imaging, and (3) site-specific pharmaco-laser therapy, with which the therapeutic efficacy of recalcitrant PWSs may be improved. "
ABSTRACT: During the last three decades, several laser systems, ancillary technologies, and treatment modalities have been developed for the treatment of port wine stains (PWSs). However, approximately half of the PWS patient population responds suboptimally to laser treatment. Consequently, novel treatment modalities and therapeutic techniques/strategies are required to improve PWS treatment efficacy. This overview therefore focuses on three distinct experimental approaches for the optimization of PWS laser treatment. The approaches are addressed from the perspective of mechanical engineering (the use of local hypobaric pressure to induce vasodilation in the laser-irradiated dermal microcirculation), optical engineering (laser-speckle imaging of post-treatment flow in laser-treated PWS skin), and biochemical engineering (light- and heat-activatable liposomal drug delivery systems to enhance the extent of post-irradiation vascular occlusion).Annals of Biomedical Engineering 02/2012; 40(2):486-506. DOI:10.1007/s10439-011-0436-9 · 3.23 Impact Factor
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ABSTRACT: Capillary malformations (CMs) are the most common vascular malformations. They are comprised of the small vessels of the capillary network in skin and mucous membranes. In the vast majority of affected individuals, CMs are isolated and not associated with any underlying abnormalities. Depending on size and location, however, they may cause significant morbidity due to disfigurement or stigmatization and, rarely, herald the presence of an underlying syndrome.Clinics in plastic surgery 01/2011; 38(1):65-73. DOI:10.1016/j.cps.2010.08.010 · 0.91 Impact Factor
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ABSTRACT: Energy intensity of the total primary energy supply (TPES), total final energy consumption (TFC) and LOSSES in the conversion from TPES to TFC were analyzed for the World, OECD and Rest of the World (ROW) countries. LOSSES increased significantly for all groups of countries due to the increase of electricity production from coal in the period studied (1971-2008). Electricity share final consumption almost doubled, increasing from 8.8% to 17.2% in the period studied. However the energy intensity of LOSSES remained practically constant, which reflects the fact that the efficiency of electricity generation from coal (the main source of electricity) remained practically constant in that period. Despite the attractiveness of end-use devices running on electricity such as computers, which is typical of modern societies, the CO2 emissions are bound to increase unless coal is replaced by less carbon emitting sources such as natural gas, renewables and nuclear energy.Energy Policy 03/2011; 39(3):1802-1805. DOI:10.1016/j.enpol.2011.01.013 · 2.58 Impact Factor