Article

EMP3 as a tumor suppressor gene for esophageal squamous cell carcinoma.

Department of Translational Cancer Research, Research Institute for Radiation Biology and Medicine (RIRBM), Hiroshima University, Hiroshima 734-8551, Japan.
Cancer letters (impact factor: 4.86). 10/2008; 274(1):25-32. DOI:10.1016/j.canlet.2008.08.021 pp.25-32
Source: PubMed

ABSTRACT EMP3, epithelial membrane protein 3, was recently reported to be a tumor suppressor gene in neuroblastomas and gliomas. We found that EMP3 was commonly repressed in esophageal squamous cell carcinoma (ESCC) cell lines by oligonucleotide microarrays. Its overexpression in ESCC cell lines caused growth inhibition with morphological changes and TERT repression. In addition to promoter hypermethylation, TSA caused repression of EMP3, indicating the involvement of histone deacetylase-regulated repressors. The post-recurrent survival after radical surgery was poorer in ESCC patients with lower EMP3 expression. We propose that EMP3 may be a tumor suppressor gene at the late step of ESCC carcinogenesis.

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Keywords

epithelial membrane protein 3
 
ESCC carcinogenesis
 
ESCC cell lines
 
esophageal squamous cell carcinoma
 
histone deacetylase-regulated repressors
 
morphological changes
 
oligonucleotide microarrays
 
post-recurrent survival
 
promoter hypermethylation
 
radical surgery
 
repression
 
TERT repression
 
tumor suppressor gene