Questioning the role of rebound firing in the cerebellum.

Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
Nature Neuroscience (Impact Factor: 15.25). 10/2008; 11(11):1256-8. DOI: 10.1038/nn.2195
Source: PubMed

ABSTRACT A key component of recent theories on cerebellar function is rebound firing in neurons of the deep cerebellar nuclei (DCN). Despite the robustness of this phenomenon in vitro, in vivo studies have provided little evidence for its prevalence. We found that intact mouse or rat DCN neurons rarely showed rebound firing under physiological conditions in vitro or in vivo. These observations necessitate a critical re-evaluation of recent cerebellar models.

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