Body mass index, respiratory function and bronchial hyperreactivity in allergic rhinitis and asthma
ABSTRACT Several studies have outlined a possible relationship between an increased body mass index (BMI) and respiratory allergic diseases, such as asthma and rhinitis. The aim of the study was to analyse the relationship between BMI and allergic diseases, including allergic rhinitis and asthma, and functional parameters, such as nasal airflow, FEV(1), and non-specific BHR to methacholine, in a cohort of navy army subjects.
The study included 100 patients with moderate-severe persistent allergic rhinitis alone, 100 with intermittent allergic asthma alone, and 100 healthy controls. All subjects were evaluated performing skin prick test, spirometry, and bronchostimulation test with methacholine. Rhinomanometry was performed in patients with rhinitis.
BMI values were significantly lower in control subjects with respect to patients with rhinitis (P=0.0002) and with respect to patients with asthma (P<0.0001). BMI was also significantly higher in males with respect to females (P=0.005). A significant relationship has been observed between some categories of BHR and BMI either in patients with rhinitis (P<0.01) or in patients with asthma (P<0.01), whereas there was no association between BMI and functional parameters.
This study provides the first evidence of a significant relationship between BMI and allergic rhinitis and between BMI and BHR in both allergic disorders.
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ABSTRACT: The aim of the study was to evaluate the association between weight status and asthma, al-lergy and respiratory symptoms in young adults with bronchiolitis in infancy. At age 26-29 years, a questionnaire was sent to 78 study subjects hospitalized for bronchiolitis at age <24 months, and 59(76%) of them answered. Asthma, allergy and respiratory symptoms were compared between overweight or obese and normal weight groups constructed by body mass index (BMI). Corresponding data were available from the follow-up visit at age 18-20 years. Population controls matched for sex and birth month and place were recruited for this 26-29 years study. Thirty-two study subjects (54.4%) were overweight (BMI >25 kg/m 2) and 8(13.6%) obese (BMI >30 kg/m 2) at age 26-29 years. Overweight was present in 21/52 study subjects (40.
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ABSTRACT: Several studies have outlined a possible relationship between an increased body mass index (BMI) and respiratory allergic diseases, such as asthma and rhinitis. Very recently, it has been demonstrated that serum adipokines, such as leptin and adiponectin, may be increased in patients with allergic rhinitis. The aim of the study was to evaluate the serum leptin and adiponectin levels in a cohort of patients with pollen-induced allergic rhinitis, before and after a single preseasonal course of sublingual immunotherapy (SLIT). A total of 41 patients (22 male and 19 female, median age 39 years) with AR due to pollen allergy, along with 34 normal subjects, were included in the study. Blood sampling for assessing serum adipokines, immunoglobulin E (IgE) levels, and eosinophils were performed in all subjects before and after the SLIT course. An increasing trend of both adipokines was observed after SLIT, albeit without statistical significance and with gender difference. Leptin was significantly related to some clinical parameters and peripheral eosinophil counts. Conversely, adinopectin showed an inverse significant correlation with peripheral eosinophils counts but only for men. In conclusion, the results of this preliminary study show that a single preseasonal SLIT course does not induce significant modifications in serum adipokines levels but induces only a slight increase.Human Immunology 12/2008; 70(1):73-8. DOI:10.1016/j.humimm.2008.10.001 · 2.28 Impact Factor
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ABSTRACT: Pharmacokinetics are typically dependent on a variety of physiological variables (e.g., age, ethnicity, or pregnancy) or pathological conditions (e.g., renal and hepatic insufficiency, cardiac dysfunction, obesity, etc.). The influence of some of these conditions has not always been thoroughly assessed in the clinical studies of antiallergic drugs. However, the knowledge of the physiological grounds of the pharmacokinetics can provide some insight for predicting the potential alterations and guiding the initial prescription strategies. It is important to recognize that both pharmacokinetic and pharmacodynamic differences between populations should be considered. The available information on drugs used for the therapy of allergic diseases is reviewed in this chapter.Drug Metabolism Reviews 02/2009; 41(3):422-54. DOI:10.1080/10837450902891527 · 6.29 Impact Factor