Prenatal exposure to acetaminophen and respiratory symptoms in the first year of life

Division of Epidemiology and Biostatistics, The University of Illinois, Chicago School of Public Health, Chicago, Illinois 60612, USA.
Annals of allergy, asthma & immunology: official publication of the American College of Allergy, Asthma, & Immunology (Impact Factor: 2.6). 10/2008; 101(3):271-8. DOI: 10.1016/S1081-1206(10)60492-9
Source: PubMed


Prevalence of asthma in developed countries increased between the 1970s and the 1990s. One factor that might contribute to the trends in asthma is the increased use of acetaminophen vs aspirin in children and pregnant women.
To examine relationships between in utero exposure to acetaminophen and incidence of respiratory symptoms in the first year of life.
A total of 345 women were recruited in the first trimester of pregnancy and followed up with their children through the first year of life. Use of acetaminophen in pregnancy was determined by questionnaire and related to incidence of respiratory symptoms.
Use of acetaminophen in middle to late but not early pregnancy was significantly related to wheezing (odd ratio, 1.8; 95% confidence interval, 1.1-3.0) and to wheezing that disturbed sleep (odds ratio, 2.1; 95% confidence interval, 1.1-3.8) in the first year of life after control for potential confounders.
This study suggests that use of acetaminophen in middle to late but not early pregnancy may be related to respiratory symptoms in the first year of life. Additional follow-up will examine relationships of maternal and early childhood use of acetaminophen with incidence of asthma at ages 3 to 5 years, when asthma diagnosis is more firmly established.

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    • "The main evidence for association between using of acetaminophen and the risk of childhood asthma develops from the International Study of Asthma and Allergies in Childhood, which included data from 72 centers in 31 countries worldwide (4). This association is constantly present in countries with different patterns of childhood febrile disorders (9-11). Countries with higher sale of Paracetamol or high Paracetamol use had a higher prevalence of asthma and other atopic disease (12). "
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    ABSTRACT: Acetaminophen exposure might be associated with increasing risk of asthma prevalence and other atopic disorders over recent decades. The present study aimed to investigate the association between acetaminophen exposure and the risk of developing childhood asthma. A case - control study was undertaken between March and September 2010 in Urmia district north west of Iran. Subjects were children aged between 2 - 8 years old. Cases were asthmatic children diagnosed based on GINA criteria (n=207) and controls were children without asthma symptoms (n=414) using 1:2 sampling method. Cases and controls were matched for age and gender. Clinical data including Acetaminophen exposure was collected by a questionnaire which completed by interviewing with parents/ guardians. Using Acetaminophen during the first year of life had no any effect on the risk of asthma (p=0.19), but amongst 2-8 years old children, this association was observed (p<0.001). There was also a doseresponseassociation between Acetaminophen consumption and risk of asthma (OR: 3.8; 95% CI; 2.15 6.59 for once per 2 to 3 month and OR: 4.2; 2.50 - 7.3 for at least one per month). Using Acetaminophen increases risk of asthma among 2 - 8 years old children. However stronger evidences are required to design evidence-based guidelines to reduce acetaminophen consumption following post - vaccination and other febrile disorders.
    10/2012; 14(10):641-6.
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    • "In 2010, Feldkamp et al. reported data from the National Birth Defects Prevention Study that showed no increased risks with maternal acetaminophen exposure for each of over 50 birth defects (Feldkamp et al., 2010). Before the pandemic, some studies had shown an association between maternal acetaminophen use and asthma in childhood (Shaheen et al., 2002; Koniman et al., 2007; Persky et al., 2008; Rebordosa et al., 2008; Garcia-Marcos et al., 2009), although not all studies had identified an association (Kang et al., 2009). Two additional studies became available after the pandemic, but these have failed to quell the controversy over this issue. "
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    ABSTRACT: Anniversaries of the identification of three human teratogens (i.e., rubella virus in 1941, thalidomide in 1961, and diethylstilbestrol in 1971) occurred in 2011. These experiences highlight the critical role that scientists with an interest in teratology play in the identification of teratogenic exposures as the basis for developing strategies for prevention of those exposures and the adverse outcomes associated with them. However, an equally important responsibility for teratologists is to evaluate whether medications and vaccines are safe for use during pregnancy so informed decisions about disease treatment and prevention during pregnancy can be made. Several recent studies have examined the safety of medications during pregnancy, including antiviral medications used to treat herpes simplex and zoster, proton pump inhibitors used to treat gastroesophageal reflux, and newer-generation antiepileptic medications used to treat seizures and other conditions. Despite the large numbers of pregnant women included in these studies and the relatively reassuring results, the question of whether these medications are teratogens remains. In addition, certain vaccines are recommended during pregnancy to prevent infections in mothers and infants, but clinical trials to test these vaccines typically exclude pregnant women; thus, evaluation of their safety depends on observational studies. For pregnant women to receive optimal care, we need to define the data needed to determine whether a medication or vaccine is "safe" for use during pregnancy. In the absence of adequate, well-controlled data, it will often be necessary to weigh the benefits of medications or vaccines with potential risks to the embryo or fetus.
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    ABSTRACT: A knowledge-based method for the 3-D reconstruction of coronary arteries using biplane angiography is described. The reconstruction problem was divided into two subproblems: (1) reconstruction of the tree skeleton and (2) reconstruction of the arterial cross section. Only the solution of the first subproblem is discussed here. Basically, the reconstruction of the tree skeleton was achieved by matching the projections of each vessel segment and subsequently backprojecting the coupled projections. As regards the matching phase, both imaging geometry and anatomical knowledge were used. In particular, owing to the allocation of epicardial vessels on a well-behaved ellipsoidlike surface, the projections of a given vessel segment must satisfy a set of geometrical conditions. These depend on the position of the vessel on the heart surface with respect to the X-ray sources. As for reconstruction of the coronary tree skeleton, an algorithm based on the imaging geometry, the bounding of the backprojection error, and a contiguity criterion was developed
    Computers in Cardiology 1989, Proceedings.; 10/1989
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