Antifungal Activities of Human Beta-Defensins HBD-1 to HBD-3 and Their C-Terminal Analogs Phd1 to Phd3

Centre for Cellular and Molecular Biology, Council of Scientific and Industrial Research, Hyderabad, India.
Antimicrobial Agents and Chemotherapy (Impact Factor: 4.45). 10/2008; 53(1):256-60. DOI: 10.1128/AAC.00470-08
Source: PubMed Central

ABSTRACT The activities of defensins HBD-1, HBD-2, and HBD-3 and their C-terminal analogs Phd1, Phd2, and Phd3 against Candida albicans were investigated. Phd1 to Phd3 showed lower-level activities than HBD-1 to HBD-3, although metabolic inhibitors did not render Phd1 to Phd3 inactive. Their activities were also less salt sensitive than those of HBD-1 to HBD-3. Confocal microscope images indicated that the initial site of action was the fungal membrane.

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