Vitiligo-like Primary Melanoma

Department of Dermatology, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA.
The American Journal of dermatopathology (Impact Factor: 1.39). 11/2008; 30(5):451-4. DOI: 10.1097/DAD.0b013e318177a423
Source: PubMed


Depigmented or hypopigmented macules and patches have been described in association to primary and metastatic melanoma. Primary melanoma presenting at the onset as a vitiliginous patch without histopathological evidence of regression seems to be a rare event. We report 2 patients with melanoma in situ that expressed clinically as vitiligo-like patches and review the possible immunologic mechanisms responsible for this unusual presentation.

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