Programmatic and research priorities for improving influenza immunization of pregnant women

Department of Gynecology and Obstetrics and Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
American journal of obstetrics and gynecology (Impact Factor: 4.7). 09/2012; 207(3 Suppl):S75-7. DOI: 10.1016/j.ajog.2012.06.078
Source: PubMed


Despite evidence regarding the benefits of influenza immunization during pregnancy for both the pregnant woman and her infant, as well as reassuring safety data, influenza vaccination rates in pregnancy have lagged. The 2009 influenza pandemic was accompanied by increased maternal vaccination rates. In this article, we review programmatic and research priorities with regard to overcoming barriers to influenza immunization of pregnant women.

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    • "Attending to claims for more evidence [66, 67], several RCTs assessing influenza vaccination in pregnancy are planned and some are ongoing [68–77]. Such RCTs focus on different populations, such as HIV-positive mothers, and factors that interfere with immunization coverage. "
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    ABSTRACT: Objective. To assess the effects of the inactivated influenza virus vaccine on influenza outcomes in pregnant women and their infants. Methods. We performed a systematic review of the literature. We searched for randomized controlled trials and cohort studies in the MEDLINE, Embase, and other relevant databases (inception to September 2013). Two researchers selected studies and extracted the data independently. We used the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach to assess the quality of the evidence. Results. We included eight studies out of 1,967 retrieved records. Influenza vaccination in pregnant women significantly reduced the incidence of influenza-like illness in mothers and their infants when compared with control groups (high-quality evidence) and reduced the incidence of laboratory-confirmed influenza in infants (moderate-quality evidence). No difference was found with regard to influenza-like illness with fever higher than 38°C (moderate-quality evidence) or upper respiratory infection (very-low-quality evidence) in mothers and infants. Conclusions. Maternal vaccination against influenza was shown to prevent influenza-like illness in women and infants; no differences were found for other outcomes. As the quality of evidence was not high overall, further research is needed to increase confidence and could possibly change these estimates.
    11/2013; 2013(2):879493. DOI:10.5402/2013/879493

  • American journal of obstetrics and gynecology 09/2012; 207(3 Suppl):S1-2. DOI:10.1016/j.ajog.2012.06.067 · 4.70 Impact Factor
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    ABSTRACT: For the 2010/11 influenza season the prenatal vaccination program was extended to all women in England and Wales irrespective of gestational age-this was a considerable shift in practice for both pregnant women and healthcare providers where the emphasis previously had been only on targeted vaccination for pregnant women with adverse risk factors for influenza infection. This paper will describe the program's operation in Stockport, UK during this season when uptake was among the highest in the England and Wales. Stockport is situated in the south east of Greater Manchester. It is a generally affluent area with a population of 295,000. Health indicators are generally higher than the regional average. The target population for influenza is just under 50,000 residents (excluding pregnant women).
    Human Vaccines & Immunotherapeutics 06/2013; 9(6). DOI:10.4161/hv.25525 · 2.37 Impact Factor
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