Aging of the Subventricular Zone Neural Stem Cell Niche

Department of Physiology and Neurobiology
Aging and Disease (Impact Factor: 3.07). 02/2011; 2(1):49-63.
Source: PubMed


The persistence of an active subventricular zone neural stem cell niche in the adult mammalian forebrain supports its continued role in the production of new neurons and in generating cells to function in repair through adulthood. Unfortunately, with increasing age the niche begins to deteriorate, compromising these functions. The reasons for this decline are not clear. Studies are beginning to define the molecular and physiologic changes in the microenvironment of the aging subventricular zone niche. New revelations from aging studies will allow for a more thorough understanding of which reparative functions are lost in the aged brain, the progression of niche demise and the possibility for therauptic intervention to improve aging brain function.

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    • "This ependymal replacement was suggested to respond to damages in the integrity of the ependymal layer due to changes in the ventricle cavity ( Luo et al . , 2006 ; Conover and Shook , 2011 ; Shook et al . , 2014 ) . "
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    ABSTRACT: Neural stem cells persist in the adult mammalian brain through life. The subventricular zone is the largest source of stem cells in the nervous system, and continuously generates new neuronal and glial cells involved in brain regeneration. During aging, the germinal potential of the subventricular zone suffers a widespread decline, but the causes of this turn down are not fully understood. This review provides a compilation of the current knowledge about the age-related changes in the neural stem cell population, as well as the fate of the newly generated cells in the aged brain. It is known that the neurogenic capacity is clearly disrupted during aging, while the production of oligodendroglial cells is not compromised. Interestingly, the human brain seems to primarily preserve the ability to produce new oligodendrocytes instead of neurons, which could be related to the development of neurological disorders. Further studies in this matter are required to improve our understanding and the current strategies for fighting neurological diseases associated with senescence.
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    • "Several groups, including ours, have previously reported the presence of label-retaining cells in the V-SVZ after thymidine analog labeling (Morshead et al., 1994; Doetsch et al., 1999), yet there is no evidence that these label-retaining cells maintain long-term progenitor properties. The present results raise the interesting possibility that following long periods of quiescence, B1 cells may be exhausted following division , a phenomenon that may explain the progressive decline in V-SVZ neurogenesis with age (Conover and Shook, 2011). We cannot, however, exclude that some B1 cells divide and one or both daughter cells remain quiescent for extended periods. "
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    Cell 06/2015; 161(7):1644-1655. DOI:10.1016/j.cell.2015.05.041 · 32.24 Impact Factor
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    • "Despite these data, which highlight the promising effects of intraparenchymal NPC delivery, comparative studies of different routes and times of transplantation (without the use of confounding immunosuppressive regimens) must be performed in order to determine the optimal spatiotemporal settings that would allow for the ideal stimulation of endogenous neurogenesis in stroke. Additionally, given that the neurogenic potential of adult NPCs declines with age (Conover and Shook, 2011), the effect of NPC transplantation in aged brains also warrants investigation . Interestingly, a recent study has shown that the local NPC transplantation (24 h post-ischemia) is capable of similar increases in neurogenesis and angiogenesis in the ischemic striatum of both young and aged mice (Tang et al., 2014). "
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