Ameloblastic Carcinoma, Secondary Type, of the Mandible: A Case Report

Assistant Professor, Department of Molecular Oral Medicine and Maxillofacial Surgery, Applied Life Sciences, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan. Electronic address: .
Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons (Impact Factor: 1.28). 10/2012; 71(1). DOI: 10.1016/j.joms.2012.09.005
Source: PubMed

ABSTRACT Ameloblastic carcinoma is a rare, odontogenic, malignant tumor that has features of ameloblastoma in addition to cytologic atypia with or without metastasis. It is classified as primary type; secondary type, intraosseous; and secondary type, peripheral according to the World Health Organization classification of 2005. Ameloblastic carcinoma, secondary type, is extremely rare, and few cases have been reported in the English-language literature. The authors report a case of ameloblastic carcinoma, secondary type, arising at the mandible in a 17-year-old Japanese boy.

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    ABSTRACT: Journal of Cranio-Maxillary Diseases Volume 3 Issue 2 July-December 2014 JCMD Asso o c ic ia g t f i u o r n i u fo q r o r H u e e lp N in o g m r N e e f u n r E o s a u d r u g y ic ABSTRACT Ameloblastic carcinoma (AC) is a rare malignant odontogenic tumor, more commonly occurring in mandible than in maxilla that has a silent presentation but aggressive course. Only 18 cases are reported in pediatric and adolescent population. Among these, 5 children died of disease (DOD), 8 are alive and status of others is unknown. Death is mainly due to metastasis and prognosis for maxillary tumors seems to be better as the reported cases have shown lesser tendency to metastasize. Hence, prognosis is determined by early and precise diagnosis, negative surgical margins and absence of distant metastasis. Therefore, after surgery, close monitoring of the patient by periodic imaging is mandatory. The purpose of this article is to report a rare lesion in a child with a review of literature pertaining to pediatric maxillary AC.
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    ABSTRACT: Ameloblastic carcinoma, secondary type, is an extremely rare odontogenic malignant tumor. The present study reports the case of a 58-year-old male with ameloblastic carcinoma that extended into the intracranial space close to the internal carotid artery. Surgical excision was performed, as headaches were being caused via compression by the mass. Small remnants of the tumor remained surrounding the internal carotid artery following surgical resection. Although the remnant tissue was not detected on magnetic resonance imaging or 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET), it was clearly visualized on (11)C-methionine PET in the early post-operative follow-up period. No neurological deficits were exhibited during the follow-up period, and (11)C-methionine PET was able to detect the remnant lesion distribution in the intracranial space. The current study presents a rare case of ameloblastic carcinoma that extended into the intracranial space. In addition, several diagnostic imaging tools were compared in order to determine the most suitable imaging modality. At present, the patient is continuing a therapeutic course of radiation and evident mass reduction has been observed. However, the therapeutic effects are currently under consideration. To the best of our knowledge, this is the first study on the effectiveness of using (11)C-methionine PET for detecting ameloblastic carcinoma with intracranial extension.
    Oncology letters 10/2014; 8(4):1509-1512. DOI:10.3892/ol.2014.2352 · 0.99 Impact Factor
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    ABSTRACT: Objective Ameloblastic carcinoma is a rare malignant odontogenic tumor. Here we present a case of a large ameloblastic carcinoma, which developed in a pre-existing ameloblastoma in the right submandibular region. Study Design The patient was an 84-year-old woman who had received several operations for ameloblastoma, including a segmental mandibulectomy. The dimensions of the tumor were 12 × 8 × 5 cm, and both benign ameloblastoma and ameloblastic carcinoma were observed histologically. Based on histological diagnosis, immunohistochemical staining and sequence analysis for p53 were performed. Results Overexpression of p53 was observed only in the ameloblastic carcinoma. Additionally, a mutation of the p53 gene in exon 5 was found by sequence analysis in the ameloblastic carcinoma. Conclusion This is the first case of ameloblastic carcinoma with a mutation of the p53 gene that has been associated with carcinomatous transformation.
    Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 11/2014; DOI:10.1016/j.oooo.2014.03.021 · 1.46 Impact Factor