Ameloblastic Carcinoma, Secondary Type, of the Mandible: A Case Report.
ABSTRACT Ameloblastic carcinoma is a rare, odontogenic, malignant tumor that has features of ameloblastoma in addition to cytologic atypia with or without metastasis. It is classified as primary type; secondary type, intraosseous; and secondary type, peripheral according to the World Health Organization classification of 2005. Ameloblastic carcinoma, secondary type, is extremely rare, and few cases have been reported in the English-language literature. The authors report a case of ameloblastic carcinoma, secondary type, arising at the mandible in a 17-year-old Japanese boy.
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ABSTRACT: Ameloblastic carcinoma (AC) is a rare malignant odontogenic tumor, more commonly occurring in mandible than in maxilla that has a silent presentation but aggressive course. Only 18 cases are reported in pediatric and adolescent population. Among these, 5 children died of disease (DOD), 8 are alive and status of others is unknown. Death is mainly due to metastasis and prognosis for maxillary tumors seems to be better as the reported cases have shown lesser tendency to metastasize. Hence, prognosis is determined by early and precise diagnosis, negative surgical margins and absence of distant metastasis. Therefore, after surgery, close monitoring of the patient by periodic imaging is mandatory. The purpose of this article is to report a rare lesion in a child with a review of literature pertaining to pediatric maxillary AC.Journal of Cranio-Maxillary Diseases. 08/2014; 3(2):141-146.
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ABSTRACT: Owing to the rarity of publications describing ameloblastic carcinoma, little is known about this entity in pediatric patients. To our knowledge, malignant transformation from an odontogenic cyst into an ameloblastic carcinoma in a pediatric patient has not been documented to date. We present the case of a 14-year-old boy in whom a large osteolytic lesion associated with an impacted right maxillary third molar germ was fortuitously detected by orthopanoramic radiography. With a preoperative clinical-radiographic diagnosis of odontogenic cyst, the patient underwent surgical enucleation of the lesion. Histologic evaluation rendered a diagnosis of follicular cyst with a focal area of ameloblastic carcinoma. The literature addressing ameloblastic carcinoma is reviewed.Oral surgery, oral medicine, oral pathology and oral radiology. 10/2013;
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ABSTRACT: Objective Ameloblastic carcinoma is a rare malignant odontogenic tumor. Here we present a case of a large ameloblastic carcinoma, which developed in a pre-existing ameloblastoma in the right submandibular region. Study Design The patient was an 84-year-old woman who had received several operations for ameloblastoma, including a segmental mandibulectomy. The dimensions of the tumor were 12 × 8 × 5 cm, and both benign ameloblastoma and ameloblastic carcinoma were observed histologically. Based on histological diagnosis, immunohistochemical staining and sequence analysis for p53 were performed. Results Overexpression of p53 was observed only in the ameloblastic carcinoma. Additionally, a mutation of the p53 gene in exon 5 was found by sequence analysis in the ameloblastic carcinoma. Conclusion This is the first case of ameloblastic carcinoma with a mutation of the p53 gene that has been associated with carcinomatous transformation.Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 11/2014; · 1.50 Impact Factor