Ameloblastic Carcinoma, Secondary Type, of the Mandible: A Case Report

Assistant Professor, Department of Molecular Oral Medicine and Maxillofacial Surgery, Applied Life Sciences, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan. Electronic address: .
Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons (Impact Factor: 1.43). 10/2012; 71(1). DOI: 10.1016/j.joms.2012.09.005
Source: PubMed


Ameloblastic carcinoma is a rare, odontogenic, malignant tumor that has features of ameloblastoma in addition to cytologic atypia with or without metastasis. It is classified as primary type; secondary type, intraosseous; and secondary type, peripheral according to the World Health Organization classification of 2005. Ameloblastic carcinoma, secondary type, is extremely rare, and few cases have been reported in the English-language literature. The authors report a case of ameloblastic carcinoma, secondary type, arising at the mandible in a 17-year-old Japanese boy.

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    • "Ameloblastic carcinoma, peripheral secondary type, is a rare odontogenic carcinoma (1), and few cases of the intracranial extension of these tumors have been reported. Ameloblastic carcinoma is defined as a rare malignant odontogenic tumor that retains the histological features of ameloblastoma and also exhibits cytological features of malignancy (1–5). 11C-methionine positron emission tomography (PET) is the most common method used to detect intracranial malignancies with high resolution, as 11C-methionine is preferentially absorbed in tissue with highly active amino acid and protein synthesis. "
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    ABSTRACT: Ameloblastic carcinoma, secondary type, is an extremely rare odontogenic malignant tumor. The present study reports the case of a 58-year-old male with ameloblastic carcinoma that extended into the intracranial space close to the internal carotid artery. Surgical excision was performed, as headaches were being caused via compression by the mass. Small remnants of the tumor remained surrounding the internal carotid artery following surgical resection. Although the remnant tissue was not detected on magnetic resonance imaging or 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET), it was clearly visualized on (11)C-methionine PET in the early post-operative follow-up period. No neurological deficits were exhibited during the follow-up period, and (11)C-methionine PET was able to detect the remnant lesion distribution in the intracranial space. The current study presents a rare case of ameloblastic carcinoma that extended into the intracranial space. In addition, several diagnostic imaging tools were compared in order to determine the most suitable imaging modality. At present, the patient is continuing a therapeutic course of radiation and evident mass reduction has been observed. However, the therapeutic effects are currently under consideration. To the best of our knowledge, this is the first study on the effectiveness of using (11)C-methionine PET for detecting ameloblastic carcinoma with intracranial extension.
    Oncology letters 10/2014; 8(4):1509-1512. DOI:10.3892/ol.2014.2352 · 1.55 Impact Factor
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    ABSTRACT: Owing to the rarity of publications describing ameloblastic carcinoma, little is known about this entity in pediatric patients. To our knowledge, malignant transformation from an odontogenic cyst into an ameloblastic carcinoma in a pediatric patient has not been documented to date. We present the case of a 14-year-old boy in whom a large osteolytic lesion associated with an impacted right maxillary third molar germ was fortuitously detected by orthopanoramic radiography. With a preoperative clinical-radiographic diagnosis of odontogenic cyst, the patient underwent surgical enucleation of the lesion. Histologic evaluation rendered a diagnosis of follicular cyst with a focal area of ameloblastic carcinoma. The literature addressing ameloblastic carcinoma is reviewed.
    10/2013; 117(5). DOI:10.1016/j.oooo.2013.08.012
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    ABSTRACT: Journal of Cranio-Maxillary Diseases Volume 3 Issue 2 July-December 2014 JCMD Asso o c ic ia g t f i u o r n i u fo q r o r H u e e lp N in o g m r N e e f u n r E o s a u d r u g y ic ABSTRACT Ameloblastic carcinoma (AC) is a rare malignant odontogenic tumor, more commonly occurring in mandible than in maxilla that has a silent presentation but aggressive course. Only 18 cases are reported in pediatric and adolescent population. Among these, 5 children died of disease (DOD), 8 are alive and status of others is unknown. Death is mainly due to metastasis and prognosis for maxillary tumors seems to be better as the reported cases have shown lesser tendency to metastasize. Hence, prognosis is determined by early and precise diagnosis, negative surgical margins and absence of distant metastasis. Therefore, after surgery, close monitoring of the patient by periodic imaging is mandatory. The purpose of this article is to report a rare lesion in a child with a review of literature pertaining to pediatric maxillary AC.
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