Article

Hypertension due to a renin-secreting juxtaglomerular cell tumor.

Department of Medicine, City Hospital, Birmingham, England, UK.
American Journal of Hypertension (impact factor: 3.18). 10/2008; 21(12):1359-61. DOI:10.1038/ajh.2008.281 pp.1359-61
Source: PubMed
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    Article: Review of juxtaglomerular cell tumor with focus on pathobiological aspect.
    Naoto Kuroda, Hiroko Gotoda, Chisato Ohe, Shuji Mikami, Keiji Inoue, Yoji Nagashima, Fredrik Petersson, Isabel Alvarado-Cabrero, Chin-Chen Pan, Ondrej Hes, Michal Michal, Zoran Gatalica
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    ABSTRACT: Juxtaglomerular cell tumor (JGCT) generally affects adolescents and young adults. The patients experience symptoms related to hypertension and hypokalemia due to renin-secretion by the tumor. Grossly, the tumor is well circumscribed with fibrous capsule and the cut surface shows yellow or gray-tan color with frequent hemorrhage. Histologically, the tumor is composed of monotonous polygonal cells with entrapped normal tubules. Immunohistochemically, tumor cells exhibit a positive reactivity for renin, vimentin and CD34. Ultrastructurally, neoplastic cells contain rhomboid-shaped renin protogranules. Genetically, losses of chromosomes 9 and 11 were frequently observed. Clinically, the majority of tumors showed a benign course, but rare tumors with vascular invasion or metastasis were reported. JGCT is a curable cause of hypertensive disease if it is discovered early and surgically removed, but may cause a fatal outcome usually by a cerebrovascular attack or may cause fetal demise in pregnancy. Additionally, pathologists and urologists need to recognize that this neoplasm in most cases pursues a benign course, but aggressive forms may develop in some cases.
    Diagnostic Pathology 08/2011; 6:80. · 1.64 Impact Factor
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