Association of MMP-3 5A/6A gene polymorphism with susceptibility to carotid atherosclerosis

VINCA Institute of Nuclear Sciences, Laboratory for Radiobiology and Molecular Genetics, P.O. Box 522, 11001 Belgrade, Serbia.
Clinical biochemistry (Impact Factor: 2.23). 10/2008; 41(16-17):1326-9. DOI: 10.1016/j.clinbiochem.2008.08.081
Source: PubMed

ABSTRACT Stromelysin-1 (MMP-3) as a key member of metalloproteinase family could have an important role in atherogenesis. The 5A/6A polymorphism in the promoter of MMP-3 gene affects the level of MMP-3 gene expression. We assessed whether the MMP-3 promoter low- and high-activity genotypes are related to susceptibility for carotid atherosclerosis (CA) in Serbian population.
The study group of case-control design consisted of 515 participants. The 265 patients with ultrasonographic evidence of carotid plaque presence were recruited for the study. The 5A/6A polymorphism was typed by RFLP-PCR.
There was significantly higher prevalence of genotypes containing 6A allele in the patients with CA compared to controls (p<0.05). The model of inheritance with the dominant effect of 6A allele gave elevated and significant OR for carotid atherosclerosis (adjusted OR 2.35, CI=1.0-5.5, p=0.048).
Subjects carrying genotypes with 6A allele had significantly higher susceptibility to carotid atherosclerosis.

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Jun 27, 2014