Clinical practice. Food allergy

Department of Paediatric Allergy, King's College London, and the Children's Allergy Service, Guy's and St. Thomas' National Health Service Foundation Trust, London.
New England Journal of Medicine (Impact Factor: 54.42). 10/2008; 359(12):1252-60. DOI: 10.1056/NEJMcp0800871
Source: PubMed
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    • "Five different allergenic proteins have been identified from hen's egg white and these include ovomucoid (Gal d 1, OVM) that represents approximately 11% of the egg white protein, ovalbumin (Gal d 2, OVA), ovotransferrin (Gal d 3), lysozyme (Gal d 4) and ovomucin (Gal d 5) with OVM being the most immunodominant allergen (Caubet et al., 2011; Tey & Heine, 2009). Studies suggest that children with food allergy including egg allergy may also suffer from other types of allergies, for example, atopic dermatitis, rhinitis and asthma (Caubet et al., 2011; Celakovska, Ettlerova, Ettler, & Vaneckova, 2011; Lack, 2008). Therefore, accurate diagnosis of food allergy is essential; however, having multiple allergies often make it difficult for proper diagnosis of food allergy. "
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    ABSTRACT: Despite its growing prevalence in westernised countries, our current understanding of the molecular mechanism(s) of food allergy remains incomplete. In this study, transcriptome profile of spleen from BALB/c mice was analysed in response to egg ovomucoid (OVM) sensitisation and challenge. Microarray analysis revealed 87 genes (91.5 fold, p50.05); 28 up-regulated and 59 downregulated. Gene ontology analysis revealed several biological processes related to hypersensitivity, inflammation or immune response. Biological network analysis illustrated connections among differentially expressed genes and several immune or hypersensitivity-related processes. Expression of five genes from microarray experiment was validated by real-time RT-PCR. Microarray analysis identified several differentially expressed genes that were not previously characterised in food allergic conditions. Results from this study may help to understand the underlying molecular events that take place in the spleen after OVM-stimulation, and may contribute as reference for future studies that may want to identify biomarkers of egg allergy.
    Food and Agricultural Immunology 09/2012; 23:227-246. DOI:10.1080/09540105.2011.615062 · 0.98 Impact Factor
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    ABSTRACT: Hazelnut (Corylus avellana) allergy varies from rather mild oral allergy symptoms to potentially life-threatening anaphylaxis and exhibits geographic and age-related variations. Severity of symptoms depends on the sensitisation profile of the patient and can partially be predicted using 'component-resolved diagnosis'. In our region (young) children predominantly exhibit sensitisation to hazelnut storage proteins Cor a 9 and Cor a 11 that is unrelated to birch pollen allergy and is generally associated with a more severe clinical outcome on consumption on raw and processed hazelnut. In contrast, adults predominantly present with an oral allergy syndrome due to an extensive cross-reactivity between the labile Cor a 1.04 and Bet v 1, the major allergen from birch (Betula verrucosa) pollen. In the absence of a cure, avoidance remains the key measure of effective management, particularly in those patients presenting with a severe form.
    Acta clinica Belgica 01/2012; 67(5):317-21. DOI:10.2143/ACB.67.5.2062683 · 0.59 Impact Factor
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    ABSTRACT: Von Nahrungsmittelallergien sind deutlich mehr Kinder als erwachsene Patienten mit atopischer Dermatitis (AD) betroffen. Sensibilisierungen in frühester Kindheit sind signifikant häufiger mit einer AD assoziiert. Drei verschiedene klinische Reaktionsmuster sind bei Patienten mit AD zu unterscheiden: i. eine Soforttypreaktion, ii. eine isolierte Spättypreaktion, iii. kombinierte Reaktionen (i + ii). Während Kinder allergische Reaktionen v. a. gegen Grundnahrungsmittel sowie Erdnuss oder Baumnüsse aufweisen, scheinen bei erwachsenen Patienten aus Mittel- und Nordeuropa die birkenpollenassoziierten Nahrungsmittel eine größere Rolle zu spielen. Defekte der Hautbarrierefunktion scheinen die Entwicklung einer Sensibilisierung gegenüber Allergenen nach vorausgegangenem epikutanem Kontakt zu erleichtern. Zur klinischen Relevanz von Defekten der Darmbarriere ebenso zu genetischen Charakteristika, die mit einem erhöhten Risiko der Entstehung einer Nahrungsmittelallergie assoziiert sind, sind weitere Untersuchungen erforderlich. Etliche Studien legen den Schwerpunkt auf hinlängliche Präventionsstrategien, wie z. B. aktuell Stillen oder Ernährung mit hydrolysierter Milchersatznahrung in den ersten 4 Lebensmonaten.
    Der Hautarzt 04/2012; 63(4). DOI:10.1007/s00105-011-2263-1 · 0.54 Impact Factor
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