Radiation Therapy for Prostate Cancer Increases Subsequent Risk of Bladder and Rectal Cancer: A Population Based Cohort Study

Department of Urology, University of Miami Miller School of Medicine, Miami, Florida, USA.
The Journal of urology (Impact Factor: 4.47). 10/2008; 180(5):2005-9; discussion 2009-10. DOI: 10.1016/j.juro.2008.07.038
Source: PubMed


Pre-prostate specific antigen era series demonstrated an increased risk of bladder cancer and rectal cancer in men who received radiotherapy for prostate cancer. We estimated the risk of secondary bladder cancer and rectal cancer after prostate radiotherapy using a contemporary population based cohort.
We identified 243,082 men in the Surveillance, Epidemiology and End Results database who underwent radical prostatectomy or radiotherapy for prostate cancer between 1988 and 2003. We estimated the incidence rate, standardized incidence ratio and age adjusted incidence rate ratio of subsequent bladder cancer and rectal cancer associated with radical prostatectomy, external beam radiotherapy, brachytherapy, and a combination of external beam radiotherapy and brachytherapy.
The relative risk of bladder cancer developing after external beam radiotherapy, brachytherapy and external beam radiotherapy-brachytherapy compared to radical prostatectomy was 1.88, 1.52 and 1.85, respectively. Compared to the general United States population the standardized incidence ratio for bladder cancer developing after radical prostatectomy, external beam radiotherapy, brachytherapy and external beam radiotherapy-brachytherapy was 0.99, 1.42, 1.10 and 1.39, respectively. The relative risk of rectal cancer developing after external beam radiotherapy, brachytherapy and external beam radiotherapy-brachytherapy compared to radical prostatectomy was 1.26, 1.08 and 1.21, respectively. The standardized incidence ratio for rectal cancer developing after radical prostatectomy, external beam radiotherapy, brachytherapy and external beam radiotherapy-brachytherapy was 0.91, 0.99, 0.68 and 0.86, respectively.
Men who receive radiotherapy for localized prostate cancer have an increased risk of bladder cancer compared to patients undergoing radical prostatectomy and compared to the general population. The risk of rectal cancer is increased in patients who receive external beam radiotherapy compared to radical prostatectomy. Patients should be counseled appropriately regarding these risks.

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    • "Seven of the ten SEER registry studies comparing second rectal cancer incidence between irradiated and non-irradiated PCa patients demonstrated that irradiated patients were at increased risk (Table 4) [6] [10] [11] [22] [23] [25] [26]. This increased risk has been mainly observed after longer durations of follow-up (i.e. "
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    ABSTRACT: The development of a radiation induced second primary cancer (SPC) is one the most serious long term consequences of successful cancer treatment. This review aims to evaluate SPC in prostate cancer (PCa) patients treated with radiotherapy, and assess whether radiation technique influences SPC. A systematic review of the literature was performed to identify studies examining SPC in irradiated PCa patients. This identified 19 registry publications, 21 institutional series and 7 other studies. There is marked heterogeneity in published studies. An increased risk of radiation-induced SPC has been identified in several studies, particularly those with longer durations of follow-up. The risk of radiation-induced SPC appears small, in the range of 1 in 220 to 1 in 290 over all durations of follow-up, and may increase to 1 in 70 for patients followed up for more than 10 years, based on studies which include patients treated with older radiation techniques (i.e. non-conformal, large field). To date there are insufficient clinical data to draw firm conclusions about the impact of more modern techniques such as IMRT and brachytherapy on SPC risk, although limited evidence is encouraging. In conclusion, despite heterogeneity between studies, an increased risk of SPC following radiation for PCa has been identified in several studies, and this risk appears to increase over time. This must be borne in mind when considering which patients to irradiate and which techniques to employ.
    Radiotherapy and Oncology 02/2014; 110(2). DOI:10.1016/j.radonc.2013.12.012 · 4.36 Impact Factor
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    • "Survivors of prostate cancer are also at risk for developing radiation-induced tumors (Zelefsky et al., 2012), which is particularly interesting given that these patients are generally treated at substantially older ages than testicular or cervical cancer patients. Recent SEER analysis for men with prostate cancer treated between 1988 and 2003 demonstrated a 1.88 relative risk of secondary bladder cancer incidence for those receiving external beam radiotherapy as compared with prostatectomy (Nieder et al., 2008), although this is influenced by tobacco exposure and may be decreasing in the era of modern radiotherapy techniques (Boorjian et al., 2007). "
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    ABSTRACT: One of the most significant effects of radiation therapy on normal tissues is mutagenesis, which is the basis for radiation-induced malignancies. Radiation-induced malignancies are late complications arising after radiotherapy, increasing in frequency among survivors of both pediatric and adult cancers. Genetic backgrounds harboring germline mutations in tumor suppressor genes are recognized risk factors. Some success has been found with using genome wide association studies to identify germline polymorphisms associated with susceptibility. The insights generated by genetics, epidemiology, and the development of experimental models are defining potential strategies to offer to individuals at risk for radiation-induced malignancies. Concurrent technological efforts are developing novel radiotherapy delivery to reduce irradiation of normal tissues, and thereby, to mitigate the risk of radiation-induced malignancies. The goal of this review is to discuss epidemiologic, modeling, and radiotherapy delivery data, where these lines of research intersect and their potential impact on patient care.
    Frontiers in Oncology 04/2013; 3:73. DOI:10.3389/fonc.2013.00073
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    • "Furthermore, one long-term complication of radiation therapy not captured in these trials is secondary malignancies. Our group has reported that men who undergo radiation for the treatment of prostate cancer are at an increased risk of developing bladder cancer [4]. Is it really worth subjecting all men with a positive surgical margin to the side effects of radiation therapy? "
    European Urology 05/2012; 61(5):1065. DOI:10.1016/j.eururo.2012.02.013 · 13.94 Impact Factor
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