Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults

Epidemiology and Public Health Group, Peninsula Medical School, Barrack Rd, Exeter EX2 5DW, UK.
JAMA The Journal of the American Medical Association (Impact Factor: 30.39). 10/2008; 300(11):1303-10. DOI: 10.1001/jama.300.11.1303
Source: PubMed

ABSTRACT Bisphenol A (BPA) is widely used in epoxy resins lining food and beverage containers. Evidence of effects in animals has generated concern over low-level chronic exposures in humans.
To examine associations between urinary BPA concentrations and adult health status.
Cross-sectional analysis of BPA concentrations and health status in the general adult population of the United States, using data from the National Health and Nutrition Examination Survey 2003-2004. Participants were 1455 adults aged 18 through 74 years with measured urinary BPA and urine creatinine concentrations. Regression models were adjusted for age, sex, race/ethnicity, education, income, smoking, body mass index, waist circumference, and urinary creatinine concentration. The sample provided 80% power to detect unadjusted odds ratios (ORs) of 1.4 for diagnoses of 5% prevalence per 1-SD change in BPA concentration, or standardized regression coefficients of 0.075 for liver enzyme concentrations, at a significance level of P < .05.
Chronic disease diagnoses plus blood markers of liver function, glucose homeostasis, inflammation, and lipid changes.
Higher urinary BPA concentrations were associated with cardiovascular diagnoses in age-, sex-, and fully adjusted models (OR per 1-SD increase in BPA concentration, 1.39; 95% confidence interval [CI], 1.18-1.63; P = .001 with full adjustment). Higher BPA concentrations were also associated with diabetes (OR per 1-SD increase in BPA concentration, 1.39; 95% confidence interval [CI], 1.21-1.60; P < .001) but not with other studied common diseases. In addition, higher BPA concentrations were associated with clinically abnormal concentrations of the liver enzymes gamma-glutamyltransferase (OR per 1-SD increase in BPA concentration, 1.29; 95% CI, 1.14-1.46; P < .001) and alkaline phosphatase (OR per 1-SD increase in BPA concentration, 1.48; 95% CI, 1.18-1.85; P = .002).
Higher BPA exposure, reflected in higher urinary concentrations of BPA, may be associated with avoidable morbidity in the community-dwelling adult population.

  • Source
    • "In addition, BPA is capable of inducing toxic effect on nonreproductive vital organs; several studies in the literature have reported absorption of large amounts of BPA through skin which has been shown to cause extensive damage to the liver and kidney in humans (Suarez et al., 2000). Moreover, it was evidenced that there was a significant relationship between urine concentration of BPA and cardiovascular disorders, type 2 diabetes and liver enzyme abnormalities in a representative sample of US population (Lang et al., 2008). "
    [Show abstract] [Hide abstract]
    ABSTRACT: Bisphenol A (BPA) is an endocrine disrupting compound widely spread in our living environment. It is a contaminant with increasing exposure to it and exerts both toxic and estrogenic effects on mammalian cells. Due to the limited information concerning the effect of BPA on the liver, the present study was designed to assess hepatic tissue injury induced by early life exposure to BPA in female rat offspring. Rat dams (n = 9) were gavaged with 0.5 and 50 mg of BPA/kg b.w./day throughout lactation until weaning. The sham group received olive oil for the same duration while the control group did not receive any injection. The liver tissue was collected from female pups at different pubertal periods (PND50, 90 and 110) to evaluate oxidative stress biomarkers, extent of DNA damage and histopathological changes. Our results indicated that early life exposure to BPA significantly increased oxidative/nitrosative stress, decreased antioxidant enzyme activities, induced DNA damage and chronic severe inflammation in the hepatic tissue in a time dependent manner. These data suggested that BPA causes long-term adverse effects on the liver, which leads to deleterious effects in the liver of female rat offspring.
    08/2015; 71. DOI:10.1016/j.jobaz.2015.01.006
  • Source
    • "Some previous studies have indicated potential links between BPA exposure and chronic diseases, including obesity, cancer, diabetes and reproductive disorders (Diamanti-Kandarakis et al., 2009; Zoeller et al., 2012). Multiple longitudinal and cross-sectional and epidemiological studies have showed that in adults, BPA exposure levels are associated with heart diseases (Bae et al., 2012; Lang et al., 2008; Melzer et al., 2012; Shankar et al., 2012). These studies include several independent analyses of NHANES indicating that the participants' "
    [Show abstract] [Hide abstract]
    ABSTRACT: Implication of environmental endocrine disruptors, such as bisphenol A (BPA), on the development of cardiopathy has been poorly investigated. The aim of the study was to investigate the effects of long-term exposure to BPA at the reference dose on the myocardium of rats, and the underlying mechanisms. Male rats received corn oil or 50 mu g/kg/day of BPA since delactation. At 24 and 48 weeks (wk), cardiac function and mitochondrial function were examined. The mRNA expression and the methylation status of PCG-1 alpha, a major regulator of mitochondrial biogenesis in cardiac muscle, were also tested. At 48 wk, BPA-exposed rats displayed cardiomyopathy, characterized by myocardium hypertrophy, cardiomyocyte enlargement, and impairment of cardiac function. At 24 wk, significantly reduced ATP production, dissipated mitochondrial membrane potential (psi m) and declined mitochondrial respiratory complex (MRC) activity in cardiomyocytes were observed in BPA-exposed rats compared with the control rats, indicating a decrease in mitochondrial function occurs before the development of cardiomyopathy. Additionally, BPA exposure decreased the expression of PGC-1 alpha and induced hypermethylation of PGC-1 alpha a in heart tissue in 24- and 48-week-old rats. The change in methylation of PGC-1 alpha was observed more pronounced in BPA-exposed rats at 48 wk. Overall, long-term BPA exposure induces cardiomyopathy in male rats, and the underling mechanism may involve the impairment of cardiac mitochondrial function and the disturbance of methylation of PGC-1 alpha.
    Toxicology 01/2015; 329. DOI:10.1016/j.tox.2015.01.001 · 3.75 Impact Factor
  • Source
    • "In 51 addition to activating estrogen receptors, BPA has been shown to 52 bind androgen and thyroid hormone receptors and is associated 53 with disrupted thyroid hormone production and signaling 54 (Chevrier et al., 2013; Gentilcore et al., 2013; Sohoni and Sumpter, 55 1998). BPA exposure has reportedly been associated with a number 56 of adverse health effects including cardiovascular disease (Lang 57 et al., 2008; Melzer et al., 2010; Shankar et al., 2012), respiratory 58 problems (Donohue et al., 2013; Spanier et al., 2012), obesity 59 (Harley et al., 2013a), prematurity (Cantonwine et al., 2010), 60 infertility (Ehrlich et al., 2012; Li et al., 2010; Meeker et al., 2010b; 61 Mok-Lin et al., 2010), and impaired cognition and behavior (Braun 62 et al., 2009, 2011b; Perera et al., 2012; Yolton et al., 2011). 63 To date, a small number of studies have examined the 64 association between prenatal exposure to BPA and child behavior, 65 with inconsistent findings. "
Show more