Control of salicylate intolerance with fish oils

Dermatopharmacology Unit, Southampton University Hospitals Trust, Southampton SO16 6YD, UK.
British Journal of Dermatology (Impact Factor: 4.1). 10/2008; 159(6):1368-9. DOI: 10.1111/j.1365-2133.2008.08830.x
Source: PubMed

ABSTRACT We report three patients with disabling salicylate-induced intolerance who experienced abrogation of symptoms following dietary supplementation with omega-3 polyunsaturated fatty acids (PUFAs). All three patients experienced severe urticaria, asthma requiring systemic steroid therapy and anaphylactic reactions. After dietary supplementation with 10 g daily of fish oils rich in omega-3 PUFAs for 6-8 weeks all three experienced complete or virtually complete resolution of symptoms allowing discontinuation of systemic corticosteroid therapy. Symptoms relapsed after dose reduction. Fish oil appears a safe and effective treatment for this difficult and often serious condition.

  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Childhood cancers are a broad range of diseases. Research on the chemopreventive potential of non-steroidal anti-inflammatory drugs, such as aspirin (acetylsalicylate) has yet to be fully directed towards childhood cancers. A prima facie hypothesis on salicylate and childhood cancer would therefore be based on several factors. Firstly, salicylate inhibits the production of inflammatory prostaglandins, which have been shown to stimulate the growth of cancer cells. Secondly, salicylate inhibits the growth of cancer cells in pre-clinical models. Thirdly, salicylate is a natural component of fruits and vegetables so it is consumed within the diet. Further research, of which some possibilities are identified, is recommended.
    ecancermedicalscience 01/2010; 4:156. DOI:10.3332/ecancer.2010.156 · 1.20 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Clinical symptoms of patients with mastocytosis may include skin reactions, but also gastrointestinal symptoms with hyperacidity and dysmotility (e.g. ulcer, diarrhea, pain). They are mostly caused by mediators derived from activated mast cells. In order to investigate the impact of leukotrienes on the clinical symptoms excretion of leukotriene B4 (LTB4) and leukotrienes C4-D4-E4 (cysteinyl-leukotrienes) into urine was studied in 9 patients with indolent systemic mastocytosis divided into a group with high and low intensity of symptoms and in 11 healthy volunteers. Leukotriene excretion was determined by ELISA and correlated with methylhistamine excretion. Patients with systemic mastocytosis with high and low intense symptoms showed significantly higher urinary excretion of cysteinyl-leukotrienes than controls. There was a positive correlation of cysteinyl-leukotriene excretion and urinary methylhistamine excretion. LTB4 excretion was also significantly increased in patients with systemic mastocytosis compared to healthy volunteers. No correlation of urinary LTB4 excretion with urinary methylhistamine was observed. The present study demonstrates that urinary excretion of LTB4 and cysteinyl-leukotrienes LTC4-D4-E4 is clearly enhanced in indolent systemic mastocytosis Hence, determination of leukotriene excretion into urine can be used as a tool in the diagnostic and in the therapeutic monitoring of systemic mastocytosis.
    Journal of physiology and pharmacology: an official journal of the Polish Physiological Society 08/2011; 62(4):469-72. · 2.72 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: On a population basis multiple nutrient deficiencies are common in developing countries, whereas in developed countries obesity and vitamin D deficiency are important health issues. While nutrient deficiencies can lead to disease, the results of clinical trials investigating the influence of supplementing various nutrients such as essential fatty acids, iron and vitamin A on upper respiratory disease have been mixed. Probiotics may have a role in the treatment of upper respiratory disease, but appropriate probiotic strain/ strains, supplement timing, as well as the dosage and method of administration continue to be debated. In clinical practice, many patients report that a milk exclusion diet is beneficial in reducing respiratory mucus production, however the scientific basis for this remains controversial. Increasing evidence indicates that zinc supplementation is beneficial in the management of upper respiratory infections. A number of clinical trials also indicate that vitamin D supplementation has a potential role in the prevention of upper respiratory disease. Optimal vitamin D levels and dosages remain to be determined.
    Nasal Physiology and Pathophysiology of Nasal Disorders, Edited by Önerci M, 01/2013: chapter Nutrition and the Upper Respiratory Tract: pages 183-190; Springer., ISBN: 978-3-642-37249-0
Show more