Article

Severe eosinophilia as a manifestation of acute graft-versus-host disease.

Department of Internal Medicine, Temple University Hospital, Philadelphia, PA 19140, USA.
Oncology (impact factor: 2.27). 10/2008; 75(3-4):134-6. DOI:10.1159/000155224 pp.134-6
Source: PubMed

ABSTRACT Significant peripheral eosinophilia in association with acute graft-versus-host disease (GVHD) is rare. Here we report a case of eosinophilia in a 30-year-old woman with relapsed acute myelogenous leukemia after an allogeneic bone marrow transplant who was treated with donor lymphocyte infusion (DLI). A month after the DLI, she developed a pruritic erythematous rash, hepatic enzyme elevations and eosinophilia that peaked at 23,300 cells/mm(3). A diagnosis of acute GVHD was made and the patient was treated with corticosteroids with a resolution of all of the aforementioned findings. The authors suggest that eosinophilia in a bone marrow transplantation patient should raise suspicion of GVHD.

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Keywords

30-year-old woman
 
acute GVHD
 
aforementioned findings
 
allogeneic bone marrow transplant
 
bone marrow transplantation patient
 
corticosteroids
 
donor lymphocyte infusion
 
eosinophilia
 
GVHD
 
hepatic enzyme elevations
 
relapsed acute myelogenous leukemia
 
Significant peripheral eosinophilia
 

Selina Luger