Aleukemic granulocytic sarcoma presenting at multiple sites: Ovary, breast and soft tissue

Department of Pathology, M.L.N. Medical College, Allahabad, India.
Rare tumors 06/2012; 4(3):e36. DOI: 10.4081/rt.2012.e36
Source: PubMed


An 18 year old female presented with the history of pain in abdomen, breast engorgement, swelling over both legs and breathlessness for three month. On clinical examination diagnosis of fibroadenoma breast was made. Ultrasonography of abdomen showed bilateral ovarian mass. Bilateral salpingo-ophrectomy was done and specimen was sent for histological examination. Two lobulated solid masses of tissues the larger one measuring 13×8×5 cm and smaller one measuring 10×7×5 cm in size received. Microscopic examination showed monomorphic population of discohesive, hyperchromatic small round cells had high N:C ratio, coarse chromatin, conspicuous nucleoli and scant to moderate amount of basophilic cytoplasm, lying in sheets and separated by fibrous strands and diffusely infiltrating the ovarian stroma. Fine needle aspiration from breast lump and leg swelling showed predominant population of blast cells. Myeloperoxidase was strongly positive and diagnosis of granulocytic sarcoma was confirmed.

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Available from: Jitendra Singh Nigam, Nov 04, 2014
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    • "It may develop following a previously diagnosed acute myeloid leukemia (AML) or may associate this pathology [1]. MS is reported in 2–14% of patients with AML [3]. In 25% of patients it precedes AML, in 15–35% it appears concomitantly with AML, and in 50% it occurs after the diagnosis of AML [1]. "
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