IL-4 in the Brain: A Cytokine To Remember

Department of Neuroscience and Graduate Program in Neuroscience, Center for Brain Immunology and Glia, University of Virginia, Charlottesville, VA 22908.
The Journal of Immunology (Impact Factor: 4.92). 11/2012; 189(9):4213-9. DOI: 10.4049/jimmunol.1202246
Source: PubMed


IL-4 has been extensively studied in the context of its role in immunity. Accumulating evidence indicates, however, that it also plays a critical role in higher functions of the normal brain, such as memory and learning. In this review, we summarize current knowledge of the basic immunology of IL-4, describe how and where this cytokine appears to operate in normal brain function, and propose a hypothesis concerning its potential role in neurological pathologies. The Journal of Immunology, 2012, 189: 4213-4219.

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