Making Alzheimer's and dementia research fit for populations

Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
The Lancet (Impact Factor: 45.22). 10/2012; 380(9851):1441-3. DOI: 10.1016/S0140-6736(12)61803-0
Source: PubMed
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    • "" While depression is less frequent in late life than in mid-life, it is more frequent in the oldest old than in the younger old, possibly because of the higher proportion of women, disability, and cognitive impairment in this group (Blazer, 2003; Luppa et al., 2010). The age distribution of a study population differs by setting (Brayne and Davis, 2012) and often an age cut-off is used as an inclusion criterion (e.g. recruitment of those aged 55+, 65+, or 75+ years). "
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    ABSTRACT: Terms to describe the behavioral and psychological symptoms commonly seen in dementia, including "Behavioral and Psychological Symptoms of Dementia" (BPSD), "non-cognitive symptoms," and "neuropsychiatric symptoms," were introduced in the 1980s and 1990s to draw attention to the heterogeneous group of symptoms that, distinct from cognitive deficits, are commonly seen in dementia and cause significant distress to patients and carers (Reisberg et al., 1987; Cummings et al., 1994; Allen and Burns, 1995; Finkel et al., 1996). BPSD include a wide range of affective, psychotic, and hyperactivity symptoms, and studies include different combinations of symptoms. These symptoms are also often studied individually outside the context of BPSD in the older population with or without cognitive impairment. Depression is most frequently studied, particularly in the older population without dementia. The relationship between dementia and depression in older people and the courses of the two disorders have been an important research topic for around 70 years (Roth, 1955).
    International Psychogeriatrics 10/2013; 26(2):1-7. DOI:10.1017/S1041610213001592 · 1.89 Impact Factor
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    ABSTRACT: Research that follows people over a period of time (longitudinal or panel studies) is increasingly recognised as of great importance in helping us to understand the ageing process and changes over time in the lives of older people. If people drop out of studies - which older people are more likely to do - the value of the study diminishes. This research draws on evidence from ongoing and previous longitudinal studies of people aged 55 and over to examine what factors encourage the retention of participants and what causes them to drop out. The research is synthesising existing evidence, drawing together the experiences of researchers involved in longitudinal studies, and collecting some new evidence about the views of survey participants. This article reports on the first part of the research by drawing together evidence from other studies. These show that there are some factors that are related to attrition whereas for others the evidence is mixed. Methods employed by these studies to reduce attrition and retain participants are examined. It must be noted that apart from the consistent finding that attrition is associated with age, education, socio-economic status and cognitive impairment, not all studies examined the same variables; some only being explored by one study. This makes it difficult to draw any further conclusions and indicates that attrition needs to be addressed in a uniform manner by more studies. This article identifies some implications for policy-makers and practitioners.
    Quality in ageing: policy, practice and research 12/2008; 9(4). DOI:10.1108/14717794200800025
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    ABSTRACT: Geriatric medicine has an encyclopaedic sweep, reflecting the complexity of both the ageing process and of our patient group. Keeping up with, and making sense of, the relevant scientific literature is challenging, especially as ageing has increased in prominence as a focus of research across many branches of the sciences and the humanities. This review of research published in 2012 in generalist, geriatric medicine and gerontology journals has been compiled with a view to extracting those aspects of research into ageing which could be considered relevant not only to the practice of geriatric medicine, but also to our understanding of the ageing process and the relationship of geriatric medicine to other medical specialties and public health. The research discussed includes new insights into global ageing and the compression of morbidity; nosological, clinical and therapeutic aspects of dementia; an innovative study on the microbiome and ageing; epidemiological perspectives into multi-morbidity; an overview of the impact of the first waves of Baby Boomers; fresh thinking on geriatric syndromes such as orthostatic hypotension, kyphosis, urinary incontinence after stroke, frailty and elder abuse; an update of the Beers criteria and the first stirrings of recognition of the longevity dividend in the biomedical literature.
    Age and Ageing 01/2013; 42(2). DOI:10.1093/ageing/afs201 · 3.11 Impact Factor
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