Krukenberg Tumor of Breast Origin
ABSTRACT The term Krukenberg tumor refers to metastatic disease of the ovary, especially those metastases containing mucin-secreting signet ring cells. Krukenberg tumor of breast origin is not a frequent condition. Case Report: A 49-year-old postmenopausal woman was admitted with pains in her breast, and masses in both breasts were biopsied. Pathology showed invasive ductal cancer with mucin-secreting signet ring cells. X-rays of the spinal column confirmed metastasis to the thoracic vertebrae, and the patient was found to have stage 4 breast cancer. Treatment consisted of chemotherapy, palliative radiotherapy and adjuvant hormone therapy with tamoxifen. The patient showed good response to treatment and was stable for 2 years. She was admitted to our clinic complaining of pelvic pain. Local recurrence, multicentric bone metastases with a right adnexal mass and ascites were detected. We performed total abdominal hysterectomy, bilateral salpingooophorectomy and appendectomy. The pathological diagnosis of the tumor revealed metastasis of signet ring cell breast cancer to the right ovary. The patient was treated with letrozole 2.5 mg/day and zoledronic acid 4 mg/day and is alive 5 months after surgery. Conclusion: Even though complete response to chemoradiotherapy in advanced breast cancer is possible, Krukenberg tumors of breast origin may be seen in the followup period.