Article

Extract from Acanthopanax senticosus harms (Siberian ginseng) activates NTS and SON/PVN in the rat brain.

Laboratory of Exercise Biochemistry, University of Tsukuba Graduate School of Comprehensive Human Sciences, Tsukuba, Japan.
Bioscience Biotechnology and Biochemistry (impact factor: 1.28). 10/2008; 72(9):2476-80. pp.2476-80
Source: PubMed

ABSTRACT The extract of the stem bark of Siberian ginseng, Acanthopanax senticosus Harms (ASH), is believed to play a body-coping role in stress through a brain noradrenergic mechanism. The present study was carried out to investigate the effect of ASH on the neuronal activation patterns of c-Fos expression in the rat brain. With ASH administration, c-Fos accumulated in both the supraoptic nuclei (SON) and paraventricular nuclei (PVN), which regulate stress response. Only the caudal regions in the nucleus of the solitary tract (NTS), a locus innervating both the SON and PVN, were activated. Such a neuro-anatomical pattern associated with ASH suggests the possible involvement of these stress-related brain loci.

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Keywords

Acanthopanax senticosus Harms
 
activated
 
ASH administration
 
body-coping role
 
c-Fos expression
 
locus innervating
 
neuro-anatomical pattern
 
neuronal activation patterns
 
nucleus
 
paraventricular nuclei
 
possible involvement
 
PVN
 
rat brain
 
Siberian ginseng
 
stem bark
 
stress-related brain loci
 
supraoptic nuclei