Self-Immolative Polymers

School of Pharmacy, University of Nottingham, Nottingham, UK.
Angewandte Chemie International Edition (Impact Factor: 11.26). 09/2008; 47(41):7804-6. DOI: 10.1002/anie.200802474
Source: PubMed
Download full-text


Available from: Cameron Alexander, Sep 27, 2015
1 Follower
48 Reads
  • ChemInform 12/2008; 39(51). DOI:10.1002/chin.200851264
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Alternatives to gadolinium-based metal chelates for Magnetic Resonance Imaging (MRI) have been reported. Magnetic resonance imaging (MRI) has been immensely valuable in diagnostic clinical imaging over the last few decades owing to its exceptional spatial and anatomical resolution. A conceptually different approach to contrast enhancement is based on chemical exchange saturation transfer (CEST). The contact relaxation enhancement is a through-bond effect and can be quite significant for directly coordinated atoms, but its strength rapidly decreases as the number of bonds increases. Chemical exchange in such cases can involve the conventional magnetization transfer (MT) techniques, which entails exchange of magnetization between a semisolid macromolecular phase and bulk water or the more recent CEST techniques that involve exchange between protons of solutes and bulk water. The discovery of paramagnetic lanthanide DOTA-tetra-amide complexes with extremely slow water exchange kinetics has further stimulated new ideas about CEST-based contrast agents.
    Chemical Reviews 05/2010; 110(5):2960-3018. DOI:10.1021/cr900284a · 46.57 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: A new light-sensitive polymer containing multiple light-sensitive triggering groups along the backbone and incorporating a quinone-methide self-immolative moiety was developed and formulated into nanoparticles encapsulating a model pharmaceutical Nile Red. Triggered burst release of the payload upon irradiation and subsequent degradation of the nanoparticles were observed. This system is designed to be versatile where the triggering group can be sensitive to a number of wavelengths.
    Journal of the American Chemical Society 07/2010; 132(28):9540-2. DOI:10.1021/ja102595j · 12.11 Impact Factor
Show more