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Mushroom polysaccharide extracts delay progression of carcinogenesis in mice.

Department of Biochemistry, School of Medicine, University of Nairobi, Nairobi, Kenya.
Journal of Experimental Therapeutics and Oncology 02/2008; 7(2):147-52.
Source: PubMed

ABSTRACT Hepatocellular carcinoma results when cancerous cells are localized in the liver. It is distributed globally with high prevalence in sub-Saharan African, southern Asia, China and Japan. Diagnosis is experimental and in many cases inaccurate due to unreliability of markers. Prognosis is poor and the cost of treatment prohibitive. Conventional radiation and chemotherapy lead to loss of hair, fertility and general weakening of the body's immune system increasing a patient's risk to infection. These observations underscore the need for improved, or additional methods of cancer diagnosis and management. We investigated the effect of polysaccharide rich Pleurotus pulmonarius fruit body extracts on progression of chemically induced hepatocellular carcinoma in CBA mice. Addition of Pleurotus pulmonarius extracts in diet delayed progression of carcinogenesis suggesting that these extracts may be useful as adjuvants to conventional cancer therapies.

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    • "Numerous reports demonstrate beneficial in vivo effects of cultivated and wild edible mushrooms. It has been proven that the polysaccharide extract of Pleurotus pulmonarius delays the progression of hepatocellular carcinoma [2]; polysaccharide from Pholiota nameko has anti-inflammatory properties in rodents [3]; Agaricus bisporus inhibits prostate tumor growth in mice [4]; Pleurotus eryngii, Grifola frondosa , and Hypsizygus marmoreus protect apolipoprotein- E deficient mice from development of atherosclerosis [5]. "
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