Depletion of dendritic cells delays ovarian cancer progression by boosting antitumor immunity.
ABSTRACT Dendritic cells (DC) and cytokines that expand myeloid progenitors are widely used to treat cancer. Here, we show that CD11c(+)DEC205(+) DCs coexpressing alpha-smooth muscle actin and VE-cadherin home to perivascular areas in the ovarian cancer microenvironment and are required for the maintenance of tumor vasculature. Consequently, depletion of DCs in mice bearing established ovarian cancer by targeting different specific markers significantly delays tumor growth and enhances the effect of standard chemotherapies. Tumor growth restriction was associated with vascular apoptosis after DC ablation followed by necrosis, which triggered an antitumor immunogenic boost. Our findings provide a mechanistic rationale for selectively eliminating tumor-associated leukocytes to promote antitumor immunity while impeding tumor vascularization and to develop more effective DC vaccines based on a better understanding of the tumor microenvironment.
Article: Customers' perceptions of salespersons' orientation and susceptibility to salespersons' influence.[show abstract] [hide abstract]
ABSTRACT: This study examined correlations of scores for salespersons' and customers' orientation, as indicated by a modified Salesperson Orientation-Customer Orientation scale, with self-reported consumers' susceptibility to salespersons' information, recommendations, and relational influence. Vehicle purchasers provided 508 useable survey responses. Correlations for customers' perceptions of both salespersons' orientation (-.39 and -.21) and customers' orientation (.39 and .24) were related to self-reports of susceptibility to salespersons' information and relational influence.Psychological Reports 11/2003; 93(2):417-8. · 0.44 Impact Factor