K-complex-induced seizures in autosomal dominant nocturnal frontal lobe epilepsy
ABSTRACT To examine in detail the relations between seizures and K-complexes in autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE).
Prolonged continuous video-EEG recording and analysis of 30 seizures in an 18-year-old woman suffering from ADNFLE with a CHRNA4 gene mutation.
Twenty-seven of 30 recorded seizures started just after a K-complex. In nine cases a sound induced a K-complex that was immediately followed by the seizure. Most seizures preceded repetitive and brief ictal restarts.
Three new characteristics have been observed in this ADNFLE patient: a K-complex is almost invariably present at seizure onset; sounds trigger some seizures; ictal restarts occur often.
These new observations--the presence of K-complexes at seizure onset and occurrence of sound-triggered seizures--support the view that ADNFLE seizures may be initiated by K-complexes.
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- "Other studies have found all NFLE episodes to occur during stage 2 NREM sleep (Derry and Johns, 2006; Montagna et al., 2008). The periodicity of the episodes was linked to different phasic events of NREM sleep (K-complexes and spindles) and to the CAP (Terzano et al., 1997; Picard et al., 1997; El Helou et al., 2008). The most striking observation is that the motor events, especially the smaller ones, follow the 20—40-s periodicity of the CAP (Terzano and Parrino, 2000). "
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