Bolus Consumption of a Specifically Designed Fruit Juice Rich in Anthocyanins and Ascorbic Acid Did Not Influence Markers of Antioxidative Defense in Healthy Humans

Journal of Agricultural and Food Chemistry (Impact Factor: 2.91). 10/2012; 60(45). DOI: 10.1021/jf300719t
Source: PubMed

ABSTRACT Exotic fruits like açai, camu-camu, and blackberries rich in natural antioxidants (ascorbic acid, anthocyanins) are marketed as "functional" food supporting a pro-/antioxidant balance. Confirming data from human studies are lacking. Within a randomized controlled crossover trial, 12 healthy non-smokers ingested 400 mL of a blended juice of these fruits or a sugar solution (control). Blood was drawn before and afterwards to determine antioxidants in plasma, markers of antioxidant capacity [trolox equivalent antioxidant capacity, Folin-Ciocalteu reducing capacity, total oxidant scavenging capacity (TOSC)] and oxidative stress [isoprostane, DNA strand breaks in leukocytes in vivo], and their resistance vs. H2O2-induced strand breaks. Compared with sugar solution, juice consumption increased plasma ascorbic acid and maintained TOSC and partly Folin-Ciocalteu reducing capacity (both P-values <0.05). Strand breaks in vivo increased after ingestion of both beverages (P<0.001), probably due to postprandial and/or circadian effects. This anthocyanin-rich fruit juice may stabilize the pro-/antioxidant balance in healthy non-smokers without affecting markers of oxidative stress.

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