Spectral Organization of the Human Lateral Superior Temporal Gyrus Revealed by Intracranial Recordings

Department of Neurosurgery.
Cerebral Cortex (Impact Factor: 8.67). 10/2012; 24(2). DOI: 10.1093/cercor/bhs314
Source: PubMed


The place of the posterolateral superior temporal (PLST) gyrus within the hierarchical organization of the human auditory cortex is unknown. Understanding how PLST processes spectral information is imperative for its functional characterization. Pure-tone stimuli were presented to subjects undergoing invasive monitoring for refractory epilepsy. Recordings were made using high-density subdural grid electrodes. Pure tones elicited robust high gamma event-related band power responses along a portion of PLST adjacent to the transverse temporal sulcus (TTS). Responses were frequency selective, though typically broadly tuned. In several subjects, mirror-image response patterns around a low-frequency center were observed, but typically, more complex and distributed patterns were seen. Frequency selectivity was greatest early in the response. Classification analysis using a sparse logistic regression algorithm yielded above-chance accuracy in all subjects. Classifier performance typically peaked at 100-150 ms after stimulus onset, was comparable for the left and right hemisphere cases, and was stable across stimulus intensities. Results demonstrate that representations of spectral information within PLST are temporally dynamic and contain sufficient information for accurate discrimination of tone frequencies. PLST adjacent to the TTS appears to be an early stage in the hierarchy of cortical auditory processing. Pure-tone response patterns may aid auditory field identification.

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    • "Thus, while MEG is well-suited to capture the dynamics of auditory processing, and has made substantial contributions to for example the investigation of cortical speech processing (Lütkenhöner and Poeppel, 2009), it is not optimal for mapping the relatively small frequency gradients within the human cortical tonotopic map. Alternatively, invasive (intracranial) electrophysiological recordings (Liégeois-Chauvel et al., 1994; Howard et al., 1996; Nourski et al., 2014) have good spatial and temporal resolution , and thereby provide a unique window into the workings of human auditory cortex. For example, using invasive electrocorticography (ECoG) a recent study observed a dynamic mirror-symmetric tonotopic gradient on postero-lateral STG, supporting that cortical tonotopy maps extend far beyond the auditory core (Striem-Amit et al., 2011; Moerel et al., 2012). "
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    ABSTRACT: While advances in magnetic resonance imaging (MRI) throughout the last decades have enabled the detailed anatomical and functional inspection of the human brain non-invasively, to date there is no consensus regarding the precise subdivision and topography of the areas forming the human auditory cortex. Here, we propose a topography of the human auditory areas based on insights on the anatomical and functional properties of human auditory areas as revealed by studies of cyto- and myelo-architecture and fMRI investigations at ultra-high magnetic field (7 Tesla). Importantly, we illustrate that-whereas a group-based approach to analyze functional (tonotopic) maps is appropriate to highlight the main tonotopic axis-the examination of tonotopic maps at single subject level is required to detail the topography of primary and non-primary areas that may be more variable across subjects. Furthermore, we show that considering multiple maps indicative of anatomical (i.e., myelination) as well as of functional properties (e.g., broadness of frequency tuning) is helpful in identifying auditory cortical areas in individual human brains. We propose and discuss a topography of areas that is consistent with old and recent anatomical post-mortem characterizations of the human auditory cortex and that may serve as a working model for neuroscience studies of auditory functions.
    Frontiers in Neuroscience 07/2014; 8(8):225. DOI:10.3389/fnins.2014.00225 · 3.66 Impact Factor
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    • "Gamma oscillations are easily measured using invasive recordings, to the point that they can be used for functional mapping purposes akin to traditional robust responses such as event-related potentials (ERPs; Jerbi et al., 2009; Nourski et al., 2012). Non-invasive EEG and MEG can be used to detect equivalent patterns of gamma oscillations as recorded invasively, though with a vastly lower signal to noise ratio which often means that source space reconstructions are required in order to detect these gamma oscillations above noise (Dalal et al., 2008; Sedley et al., 2012). "
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    ABSTRACT: Cortical gamma oscillations occur alongside perceptual processes, and in proportion to perceptual salience. They have a number of properties that make them ideal candidates to explain perception, including incorporating synchronized discharges of neural assemblies, and their emergence over a fast timescale consistent with that of perception. These observations have led to widespread assumptions that gamma oscillations' role is to cause or facilitate conscious perception (i.e., a "positive" role). While the majority of the human literature on gamma oscillations is consistent with this interpretation, many or most of these studies could equally be interpreted as showing a suppressive or inhibitory (i.e., "negative") role. For example, presenting a stimulus and recording a response of increased gamma oscillations would only suggest a role for gamma oscillations in the representation of that stimulus, and would not specify what that role were; if gamma oscillations were inhibitory, then they would become selectively activated in response to the stimulus they acted to inhibit. In this review, we consider two classes of gamma oscillations: "broadband" and "narrowband," which have very different properties (and likely roles). We first discuss studies on gamma oscillations that are non-discriminatory, with respect to the role of gamma oscillations, followed by studies that specifically support specifically a positive or negative role. These include work on perception in healthy individuals, and in the pathological contexts of phantom perception and epilepsy. Reference is based as much as possible on magnetoencephalography (MEG) and electroencephalography (EEG) studies, but we also consider evidence from invasive recordings in humans and other animals. Attempts are made to reconcile findings within a common framework. We conclude with a summary of the pertinent questions that remain unanswered, and suggest how future studies might address these.
    Frontiers in Human Neuroscience 09/2013; 7:595. DOI:10.3389/fnhum.2013.00595 · 3.63 Impact Factor
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    ABSTRACT: Electrical stimulation of the auditory nerve with a cochlear implant (CI) is the method of choice for treatment of severe-to-profound hearing loss. Understanding how the human auditory cortex responds to CI stimulation is important for advances in stimulation paradigms and rehabilitation strategies. In this study, auditory cortical responses to CI stimulation were recorded intracranially in a neurosurgical patient to examine directly the functional organization of the auditory cortex and compare the findings with those obtained in normal-hearing subjects. The subject was a bilateral CI user with a 20-year history of deafness and refractory epilepsy. As part of the epilepsy treatment, a subdural grid electrode was implanted over the left temporal lobe. Pure tones, click trains, sinusoidal amplitude-modulated noise, and speech were presented via the auxiliary input of the right CI speech processor. Additional experiments were conducted with bilateral CI stimulation. Auditory event-related changes in cortical activity, characterized by the averaged evoked potential and event-related band power, were localized to posterolateral superior temporal gyrus. Responses were stable across recording sessions and were abolished under general anesthesia. Response latency decreased and magnitude increased with increasing stimulus level. More apical intracochlear stimulation yielded the largest responses. Cortical evoked potentials were phase-locked to the temporal modulations of periodic stimuli and speech utterances. Bilateral electrical stimulation resulted in minimal artifact contamination. This study demonstrates the feasibility of intracranial electrophysiological recordings of responses to CI stimulation in a human subject, shows that cortical response properties may be similar to those obtained in normal-hearing individuals, and provides a basis for future comparisons with extracranial recordings.
    Journal of the Association for Research in Otolaryngology 03/2013; 14(3). DOI:10.1007/s10162-013-0382-3 · 2.60 Impact Factor
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