Antifungal effect of silver nanoparticles on dermatophytes

Department of Microbiology, College of Natural Sciences, Kyungpook National University, Daegu 702-701, Korea.
Journal of Microbiology and Biotechnology (Impact Factor: 1.53). 09/2008; 18(8):1482-4.
Source: PubMed


Spherical silver nanoparticles (nano-Ag) were synthesized and their antifungal effects on fungal pathogens of the skin were investigated. Nano-Ag showed potent activity against clinical isolates and ATCC strains of Trichophyton mentagrophytes and Candida species (IC80, 1-7 microg/ml). The activity of nano-Ag was comparable to that of amphotericin B, but superior to that of fluconazole (amphotericin B IC80, 1-5 microg/ml; fluconazole IC80, 10- 30 microg/ml). Additionally, we investigated their effects on the dimorphism of Candida albicans. The results showed nano-Ag exerted activity on the mycelia. Thus, the present study indicates nano-Ag may have considerable antifungal activity, deserving further investigation for clinical applications.

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Available from: Keuk-Jun Kim, Nov 13, 2014
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    • "SNPs at 100 ppm totally inhibited the bacterial growth, but the activity against mold and dermatophytes was low; bacteria and molds exhibited resistance against SNPs at 50 ppm concentration (Falkiewicz-Dulik and macura et al. 2008). In case of C.albicans also, SNPs are found to be cytotoxic disrupting the cell membrane and formation of pits and pores on membrane surface, subsequently leads to cell death (Kim et al. 2008, 2009). SNPs have found its application against fungal infection and in biostabilization of footwear materials. "
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    03/2015; DOI:10.1007/s13204-015-0426-6
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    • "ranging from 1 to 100 nm. Silver nanoparticles represent a prominent nanoproduct with potential applications in medicine and hygiene because of the antibacterial effects (Lok et al., 2006; Kim et al., 2007; Ayala-Núñez et al., 2009) antiviral actions (Elechiguerra et al., 2005; Mehrbod et al., 2009) and antifungal activity (Kim et al., 2008a). They also promote wound healing by playing a role in cytokine modulation (Wong et al., 2009). "
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    • "According with the definition of fungistatic versus fungicidal effect [40], in our study AgNPs were found to present a fungicidal effect, since cultures treated with the MIC were unable to recover after treatment, even after inoculation in fresh culture medium in successive subcultures. The antifungal properties of AgNPs against C. albicans have been demonstrated in some other studies, although reported MIC values are different from the ones we found in this work [21], [24], [28], [37], [38], [41], [42]. Such differences could be due to the nature of the particles used, the difference in size being particularly important. "
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