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Antifungal effect of silver nanoparticles on dermatophytes.

Department of Microbiology, College of Natural Sciences, Kyungpook National University, Daegu 702-701, Korea.
Journal of Microbiology and Biotechnology (Impact Factor: 1.32). 09/2008; 18(8):1482-4.
Source: PubMed

ABSTRACT Spherical silver nanoparticles (nano-Ag) were synthesized and their antifungal effects on fungal pathogens of the skin were investigated. Nano-Ag showed potent activity against clinical isolates and ATCC strains of Trichophyton mentagrophytes and Candida species (IC80, 1-7 microg/ml). The activity of nano-Ag was comparable to that of amphotericin B, but superior to that of fluconazole (amphotericin B IC80, 1-5 microg/ml; fluconazole IC80, 10- 30 microg/ml). Additionally, we investigated their effects on the dimorphism of Candida albicans. The results showed nano-Ag exerted activity on the mycelia. Thus, the present study indicates nano-Ag may have considerable antifungal activity, deserving further investigation for clinical applications.

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