Article

Genomic analysis of zinc homeostasis in Mycobacterium tuberculosis.

Dipartimento di Genetica e Microbiologia, Università degli Studi di Pavia, Italy.
FEMS Microbiology Letters (impact factor: 2.04). 09/2008; 287(1):1-7. DOI:10.1111/j.1574-6968.2008.01320.x
Source: PubMed

ABSTRACT Zn2+ is involved in several cellular processes and the maintenance of cellular Zn2+ status is essential for life. Therefore, an improved understanding of zinc acquisition and metabolism is of great significance, especially in important pathogens such as Mycobacterium tuberculosis whose capacity to survive within the phagosomal compartment is fundamental for its pathogenicity. A crucial point is the bacterial ability to compete with the host for nutrients, and the acquisition of metal ions, such as iron and zinc.

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Keywords

bacterial ability
 
crucial point
 
great significance
 
improved understanding
 
Mycobacterium tuberculosis
 
phagosomal compartment
 
zinc acquisition