Potential Misclassification of a Case of SIDS: Maternal and Neonatal Hair Analysis for Cocaine and Heroin
ABSTRACT Verification of illicit drug use by the mother during pregnancy is crucial when an attempt is made to correlate such exposure with fetal outcome. However, maternal report has been shown to be very inaccurate, and urine and blood testing for illicit drugs are positive only during the few days after their use . Meconium testing is a very sensitive tool to detect in utero exposure to drugs; however, it has to be performed during the first days of life . We have recently reported the sensitivity and specificity of hair analysis for intrauterine cocaine exposure; accumulation of cocaine in the hair is maintained for the life of neonatal hair . We describe a case in which analysis of maternal and neonatal hair yielded important information about drug history, which was not elicited from the mother.
- SourceAvailable from: clinchem.org[Show abstract] [Hide abstract]
ABSTRACT: Baumgartner et al. found that the hair of heroin users contains a minute amount of morphine, and that testing hair for morphine can provide useful information on previous heroin use by an addict. In their method, a sample of hair is extracted for 2 hr with hot methanol, the solvent is evaporated, and the extract is radioimmunoassayed for morphine. We are now using hair analysis routinely to assess previous drug use by heroin or cocaine addicts.Clinical Chemistry 12/1981; 27(11):1952-3. · 7.91 Impact Factor
- Clinical Chemistry 12/1988; 34(11):2372-3. · 7.91 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Cocaine was detected in hair of all of 13 patients from a drug-abuse clinic who acknowledged having used the drug in varying amounts during the last 6 mo. A correlation was observed between the amount of drug used and the quantity trapped in the interior of hair grown during the 6-mo period. In contrast to hair analysis, urinalysis by thin-layer chromatography was negative in all cases, indicating that cocaine had not been used by the patients within 48-72 hr before the urine collection. Hair analysis thus appears to be far superior to urinalysis for establishing histories of drug use.Journal of Nuclear Medicine 10/1982; 23(9):790-2. · 6.16 Impact Factor