Preliminary Biological and Phytochemical Investigation of two Nigerian Medicinal Plants
ABSTRACT Abstract A. total often extracts of two plants Pleioceras barteri Baill and Marsdenia latifolia Schum, normally used in folkloric medicine in Nigeria have been screened for their phytoconstituents and implicated biological activity. Nine (90%) of the extracts gave positive test for alkaloids, four (40%) for flavonoids, five (50%) for saponins, two (20%) for tannins, and four (40%) for sterols. Their antibacterial, hippocratic activity is discussed while the abortifacient activity of Pleioceras barteri is highlighted.
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ABSTRACT: Typha angustifolia Linn. a common plant of wetlands, is an unexploited taxon which can be used as a good source of food, medicines and fibres. Agave cantala Roxb. A commonly cultivated worldwide as an ornamental plant. It has since naturalised in many regions and grows wild in Europe, South Africa, Australia, Newzealand and in India. Typha & Agave plant species have been also identified as, a few of the most promising domestic, commercial fibre yielding plants from the ancient literature sources and they have been used by the various primitive communities for making cordage, nets, mats, hats and tuff roofs etc.. It is with this background, the present study it has been taken up to detect the preliminary screening of antimicrobial activity of various fibre components of the above biological fibre yielding plants. All the data is recorded in this paper. The results are mostly conformity of the medicinal uses and they are discussed in detail in this article belongs to the first hand information and sparse information is available related to its other uses as per literature sources.Science India. 07/2011; 33-40(Vol.14):7.
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ABSTRACT: Flavonoids are ubiquitous in photosynthesising cells and are commonly found in fruit, vegetables, nuts, seeds, stems, flowers, tea, wine, propolis and honey. For centuries, preparations containing these compounds as the principal physiologically active constituents have been used to treat human diseases. Increasingly, this class of natural products is becoming the subject of anti-infective research, and many groups have isolated and identified the structures of flavonoids possessing antifungal, antiviral and antibacterial activity. Moreover, several groups have demonstrated synergy between active flavonoids as well as between flavonoids and existing chemotherapeutics. Reports of activity in the field of antibacterial flavonoid research are widely conflicting, probably owing to inter- and intra-assay variation in susceptibility testing. However, several high-quality investigations have examined the relationship between flavonoid structure and antibacterial activity and these are in close agreement. In addition, numerous research groups have sought to elucidate the antibacterial mechanisms of action of selected flavonoids. The activity of quercetin, for example, has been at least partially attributed to inhibition of DNA gyrase. It has also been proposed that sophoraflavone G and (-)-epigallocatechin gallate inhibit cytoplasmic membrane function, and that licochalcones A and C inhibit energy metabolism. Other flavonoids whose mechanisms of action have been investigated include robinetin, myricetin, apigenin, rutin, galangin, 2,4,2'-trihydroxy-5'-methylchalcone and lonchocarpol A. These compounds represent novel leads, and future studies may allow the development of a pharmacologically acceptable antimicrobial agent or class of agents.International Journal of Antimicrobial Agents 12/2005; 26(5):343-56. · 4.42 Impact Factor
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ABSTRACT: Euphorbia antiquorum L. is conspicuously and regularly represented in the flora of the Rayalaseema region, A.P, India and is used as insecticide, fungicide, anti-hyperglycaemic, cytotoxic agent, for curing skin infections, applied to cosmetic injuries and wounds for speedy healing. E. antiquorum containing latex, distributed in laticiferous tissue. Its extracts containing flavonoids as the principal physiologically active constituents; this class of natural products is becoming the subject of antibacterial activity. The present study is focussed to isolate and quantify latex from phylloclades, roots of E. antiquorum and investigate their antibacterial activities. Antibacterial activity was tested against Pseudomonas aeruginosa, Klebsiella pneumonia, Proteus vulgaris, Escherichia coli, Streptococcus anginosus and Bacillus subtilis. Disc method of Bauer-Kirby was found that, flavonoids of E. antiquorum latex were effective against G +ve and G -ve bacterial species. 30 μg/ml concentration of extract is sufficient to constrain bacterial growth. Qualitative analysis of flavonoids and quantitative analysis of total flavonoids has been carried out and the studies revealed that the pure latex of E. antiquorum contained 7.54 mg/g total flavonoid. 1. INTRODUCTION India has a rich source of plants and several plant parts/products are known to exhibit medicinal properties for the treatment of various diseases . Sometimes the presence of secondary metabolites such as flavonoids, antioxidants, tannins etc. in plants strongly supports their use in the treatment of wounds, burns and haemorrhoids in herbal medicine [2-3]. Euphorbiaceae s.l., is one of the largest families of flowering plants, composed of over 300 genera and 8,000 species, grown on wide range of habitats . The implication is that, different Euphorbiaceae species are tend to manufacture a wide range of secondary plant substances to aid response to a disparity of stimuli in their particular habitat . Many cultures around the world have used Euphorbiaceae members for its believed medicinal properties. Secondary metabolites such as saponins, flavonoids and tannins from E. heterophylla exhibited good activity against xanthine oxidase enzymes . Species such as E. polycarpa and E. hirta are used for treatment of different ailments in the ancient Ayurveda system . Even today, many Euphorbiaceae plant concoctions, fresh latex and teas are used in alternative medicine. E. tirucalli contains large quantities of terpenes and sterols and