Preliminary Biological and Phytochemical Investigation of two Nigerian Medicinal Plants

Pharmaceutical Biology (Impact Factor: 1.24). 09/2008; 24(3):147-153. DOI: 10.3109/13880208609060892


Abstract A. total often extracts of two plants Pleioceras barteri Baill and Marsdenia latifolia Schum, normally used in folkloric medicine in Nigeria have been screened for their phytoconstituents and implicated biological activity. Nine (90%) of the extracts gave positive test for alkaloids, four (40%) for flavonoids, five (50%) for saponins, two (20%) for tannins, and four (40%) for sterols. Their antibacterial, hippocratic activity is discussed while the abortifacient activity of Pleioceras barteri is highlighted.

16 Reads
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Sriharikota Island is important because of its rich vegetational diversity and for the fact that it is the site of a Rocket Launching Station built by the Indian Space Research Organization (ISRO). An aboriginal tribe called 'Yanadi' dwells in a few tribal pockets on Sriharikota Island. However, a few aged tribal men are still able to furnish information regarding their traditional practices of medicines and recipes. There is an urgent need to conserve their herbal wealth and preserve their traditional knowledge for the benefit of modern society. It is with this background, along with the need to give a primary scientific basis to the tribal medicinal lore of Sriharikota Island, that a preliminary screening of antimicrobial (antibacterial and antifungal) activity screening was conducted for 81 tribal medicinal samples based on their medicinal importance and endemism/rare occurrence on the island. Of these 81 samples, 28 have shown positive response for antimicrobial tests. Among these 8 species, namely Alangium salvifolium, Aristolochia indica, Ctrullus colocynthis, Datura stramonium, Ficus religiosa, Holoptelia integrifolia, Lawsonia innermis and Ventilago madaraspatana have shown congizable immunity zone of inhibition (i.e. above 20 mm). All the data is recorded in this paper. The results are mostly in conformity of the medicinal uses and they are discussed in detail in this article.
  • [Show abstract] [Hide abstract]
    ABSTRACT: Informations on root flavonoids have been extensively reviewed and their functional diversity critically appraised. Root flavonoids play significant roles in protecting the plants against pests and diseases, regulating root growth and functions, influencing different aspects of nitrogen cycle and exerting allelopathic growth effects. They also constitute an essential source of Pharmaceuticals. An exhaustive list of flavonoids which are of significance in relation to these properties has been compiled. A thorough understanding of the flavonoid composition, level, metabolism and regulation in the roots of various plants may help us in developing several applied topics. Safe and specific chemicals against root pests; chemicals regulating root growth and mineral nutrition; plant varieties resistant to root pests and adverse allelopathic effects; an improved nitrogen economy in agroecosystems; desirable varieties of medicinal plants, in whose roots flavonoids are the active principles; in vitro systems for flavonoid production obtained from root cultures, at a commercial scale.
    The Botanical Review 01/1990; 56(1):1-84. DOI:10.1007/BF02858531 · 1.83 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Activity of the flavonoids apigenin, baicalin and galangin against sensitive and antibiotic resistant strains of Staphylococculs aureus, Enterococcus faecalis, E. faecium, Escherichia coli and Pseudomonas aeruginosa was investigated. Using an agar dilution assay, galangin was shown to have a minimum inhibitory concentration (MIC) of 25 to 50 microg/mL against all six strains of S. aureus but negligible activity against the othe species. Apigenin displayed only marginal activity against S. aureus and no activity was detected from baicalin. In inhibition curve studies, galangin caused a 100,000-fold decrease in the viability of a growing population of S. aureus NCTC 6571 within the first two hours of treatment. Decreases in viability of S. aureus NCTC 11561 and NCIMB 9968 populations were also observed.
    Microbiological Research 02/2003; 158(4):281-9. DOI:10.1078/0944-5013-00206 · 2.56 Impact Factor
Show more