Article

Preliminary Biological and Phytochemical Investigation of two Nigerian Medicinal Plants

09/2008; 24(3):147-153. DOI: 10.3109/13880208609060892

ABSTRACT Abstract A. total often extracts of two plants Pleioceras barteri Baill and Marsdenia latifolia Schum, normally used in folkloric medicine in Nigeria have been screened for their phytoconstituents and implicated biological activity. Nine (90%) of the extracts gave positive test for alkaloids, four (40%) for flavonoids, five (50%) for saponins, two (20%) for tannins, and four (40%) for sterols. Their antibacterial, hippocratic activity is discussed while the abortifacient activity of Pleioceras barteri is highlighted.

0 Bookmarks
 · 
138 Views
  • [Show abstract] [Hide abstract]
    ABSTRACT: The ethanolic extract of leaves of Acalypha hispida was evaluated for phytochemical, cytotoxic and antibacterial activities. Phytochemical studies revealed the presence of flavonoids, saponins, glycosides, reducing sugars and steroids. Cytotoxic activity was investigated by brine shrimp (Artemia salina) lethality assay. The extract showed potent cytotoxic effect (LC 50 19.95µg/ml) which is comparable to standard cytotoxic drug chloramphenicol (LC 50 7µg/ml). Antibacterial activity was tested by disk diffusion method. The extract exhibited significant antibacterial activity against Salmonella typhe and moderate activity against Enterococcus coli, Streptococcus saprophyticus and Streptococcus agalactin whereas Shigella dysentery found resistant at 250µg/disc and 500µg/disc. INTRODUCTION: The history of medicinal plants in remedy of different diseases is well established. Various species of different family of plant and other sources contribute in the development of present therapeutic processes. As a part of our ongoing research in Pharmacy Discipline, Khulna University phytochemical, cytotoxic and antimicrobial activities were studied in this experiment on Acalypha hispida.
    International Journal of Pharmaceutical Sciences and Research (IJPSR). 05/2012; 3(06):1705-1708.
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Euphorbia antiquorum L. is conspicuously and regularly represented in the flora of the Rayalaseema region, A.P, India and is used as insecticide, fungicide, anti-hyperglycaemic, cytotoxic agent, for curing skin infections, applied to cosmetic injuries and wounds for speedy healing. E. antiquorum containing latex, distributed in laticiferous tissue. Its extracts containing flavonoids as the principal physiologically active constituents; this class of natural products is becoming the subject of antibacterial activity. The present study is focussed to isolate and quantify latex from phylloclades, roots of E. antiquorum and investigate their antibacterial activities. Antibacterial activity was tested against Pseudomonas aeruginosa, Klebsiella pneumonia, Proteus vulgaris, Escherichia coli, Streptococcus anginosus and Bacillus subtilis. Disc method of Bauer-Kirby was found that, flavonoids of E. antiquorum latex were effective against G +ve and G -ve bacterial species. 30 μg/ml concentration of extract is sufficient to constrain bacterial growth. Qualitative analysis of flavonoids and quantitative analysis of total flavonoids has been carried out and the studies revealed that the pure latex of E. antiquorum contained 7.54 mg/g total flavonoid. 1. INTRODUCTION India has a rich source of plants and several plant parts/products are known to exhibit medicinal properties for the treatment of various diseases [1]. Sometimes the presence of secondary metabolites such as flavonoids, antioxidants, tannins etc. in plants strongly supports their use in the treatment of wounds, burns and haemorrhoids in herbal medicine [2-3]. Euphorbiaceae s.l., is one of the largest families of flowering plants, composed of over 300 genera and 8,000 species, grown on wide range of habitats [4]. The implication is that, different Euphorbiaceae species are tend to manufacture a wide range of secondary plant substances to aid response to a disparity of stimuli in their particular habitat [5]. Many cultures around the world have used Euphorbiaceae members for its believed medicinal properties. Secondary metabolites such as saponins, flavonoids and tannins from E. heterophylla exhibited good activity against xanthine oxidase enzymes [6]. Species such as E. polycarpa and E. hirta are used for treatment of different ailments in the ancient Ayurveda system [7]. Even today, many Euphorbiaceae plant concoctions, fresh latex and teas are used in alternative medicine. E. tirucalli contains large quantities of terpenes and sterols and
  • [Show abstract] [Hide abstract]
    ABSTRACT: The ethanolic extract of leaves of Acalypha hispida was evaluated for phytochemical, cytotoxic and antibacterial activities. Phytochemical studies revealed the presence of flavonoids, saponins, glycosides, reducing sugars and steroids. Cytotoxic activity was investigated by brine shrimp (Artemia salina) lethality assay. The extract showed potent cytotoxic effect (LC 50 19.95µg/ml) which is comparable to standard cytotoxic drug chloramphenicol (LC 50 7µg/ml). Antibacterial activity was tested by disk diffusion method. The extract exhibited significant antibacterial activity against Salmonella typhe and moderate activity against Enterococcus coli, Streptococcus saprophyticus and Streptococcus agalactin whereas Shigella dysentery found resistant at 250µg/disc and 500µg/disc. INTRODUCTION: The history of medicinal plants in remedy of different diseases is well established. Various species of different family of plant and other sources contribute in the development of present therapeutic processes. As a part of our ongoing research in Pharmacy Discipline, Khulna University phytochemical, cytotoxic and antimicrobial activities were studied in this experiment on Acalypha hispida.