Effect of Recovery Duration between Two Bouts of Running on Bone Metabolism.

2Biomedical, Life and Health Sciences Research Centre, School of Science and Technology, Nottingham Trent University, UK
Medicine and science in sports and exercise (Impact Factor: 4.46). 10/2012; DOI: 10.1249/MSS.0b013e3182746e28
Source: PubMed

ABSTRACT PURPOSE: Strenuous, endurance exercise increases biochemical markers of bone resorption but not formation, although the effect of recovery duration between consecutive bouts of exercise is unknown. We examined the effect of recovery duration on the bone metabolic response to two bouts of running. METHODS: Ten physically-active men completed two, 9-d trials. On days 4 and 5, participants completed two, 60 min bouts of running at 65% VO2max separated by either a 23 h (LONG) or 3 h (SHORT) recovery period. Osteoprotegerin (OPG), parathyroid hormone (PTH), albumin-adjusted calcium (ACa), and phosphate (PO4) were measured from blood samples obtained before and for 3 h after exercise, and on four follow-up days (days 6-9). Markers of bone resorption [C-terminal telopeptide region of collagen type 1 (β-CTX)] and bone formation [N-terminal propeptides of procollagen type 1 (P1NP) and bone alkaline phosphatase (bone ALP)] were measured in early morning, fasted samples on days 4 to 9. RESULTS: There were no significant changes in β-CTX, P1NP or bone ALP with either protocol. OPG, PTH, ACa and PO4 concentrations increased with all exercise bouts but the response to the second bout was not altered by recovery duration. CONCLUSION: Two, 60 min bouts of running at 65% VO2max separated by either 23 h or 3 h had no effect on markers of bone resorption or formation from 1 to 4 days postexercise. Reducing recovery duration from 23 h to 3 h between two bouts of running did not alter the increase in OPG, PTH, ACa and PO4 to the second bout.

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    ABSTRACT: Context: Lower PTH concentrations reported in the hours after acute, endurance exercise compared with preexercise levels might be influenced by factors such as circadian fluctuations. Objective: The objective of the study was to compare postexercise PTH concentrations with a nonexercising control group. Design and Setting: A laboratory-based study with a crossover design, comparing a 60-minute (at 10:30 am) bout of treadmill running at 65% of the maximal rate of oxygen uptake (exercise) with semirecumbent rest (CON). Blood samples were obtained immediately before (baseline 10:15 am) and after (11:30 am) exercise and during recovery (12:30 am, 1:30 pm, and 12:15 pm). Participants: Ten physically active men (mean±1 SD, age 26±5 y; body mass 78.3±5.8 kg; maximal rate of oxygen uptake 57.3±6.9 mL/kg(-1)·min(-1)) participated in the study. Main Outcome Measures: PTH, albumin-adjusted calcium, and phosphate concentrations were measured. Results: PTH concentrations increased (+85%, P<.01) during exercise and were higher than in CON immediately at the end of exercise (4.5±1.9 vs 2.6±0.9 pmol/L(-1), P<.05). In the postexercise period (12:30-12:15 pm), PTH was not different compared with baseline but was lower compared with CON at 1:30 pm (-22%; P<.01) and tended to be lower at both 12:30 pm (-12%; P= .063) and 2:15 pm (-13%; P= .057). Exercise did not significantly affect the albumin-adjusted calcium concentrations, whereas phosphate was higher than CON immediately after exercise (1.47±0.17 vs 1.03±0.17 pmol/L(-1), P<.001) and was lower at 1:30 pm (-16%:P<.05). Conclusions: Lower PTH concentrations after acute endurance running compared with a rested control condition suggest a true effect of exercise.
    The Journal of Clinical Endocrinology and Metabolism 01/2014; 99(5):jc20133027. DOI:10.1210/jc.2013-3027 · 6.31 Impact Factor


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May 19, 2014