Article

The Shear Stress of Busting Blood Clots

Department of Mechanical Engineering and the Maurice Kanbar Center for Biomedical Engineering, the Cooper Union for the Advancement of Science and Art, New York, USA.
New England Journal of Medicine (Impact Factor: 54.42). 10/2012; 367(14):1361-3. DOI: 10.1056/NEJMcibr1207994
Source: PubMed

ABSTRACT Systemic delivery of tissue-type plasminogen activator (t-PA) to dissolve a thrombus after a heart attack or stroke is accompanied by the risk of hemorrhage. A recent study shows the use of nanoaggregates to target t-PA to the thrombus in mouse models of mesenteric injury and pulmonary embolism.

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