Melasma: Successful treatment with pidobenzone 4% (K5 (R) lipogel)
ABSTRACT Melasma (a term derived from the Greek word "melas" meaning black) is an acquired blotchy, irregularly patterned, brown or sometimes gray brown hypermelanosis of the face and occasionally the neck. Its etiology is poorly understood but mainly related to sunlight and genetic predisposition. Melasma seems to be more frequent in darker skinned people, especially women. Its treatment is always difficult and the condition usually relapses. The treatment with pidobenzone 4% (K5 lipogel), twice per day for 16 weeks has proved to be safe and effective. Pidobenzone 4% lipogel, according to the present study, seems also to represent a useful, reliable, and safe treatment of the different types of melasma.
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- "Different combined preparations have been used during the time, with the goal of increasing the efficacy and reducing the side effects of the depigmenting drugs in the treatment of melasma. The most widely used association is HQ þ RA þ steroid, namely the so-called Kligman and Willis' formula (5% HQ, 0.1% RA, and 0.1% dexamethasone ) , the most common combination for treating melasma worldwide. Other effective combination preparations that associated 4% HQ, 0.05% RA, and 0.01% flucinolone acetonide  proved to be superior to HQ and RA alone. "
Article: Therapeutical Approaches in Melasma[Show abstract] [Hide abstract]
ABSTRACT: Melasma (cloasma) is a typical hypermelanosis and a common dermatologic skin disease that involves sun-exposed areas of the skin. It mostly affects women of reproductive age. Solar and ultraviolet exposure are the most crucial etiologic factors. Pregnancy, certain endocrine disorders and hormonal treatments, cosmetics, phototoxic drugs, and antiseizure medications are well-known inducing and exacerbating factors. A classification of melasma is based on Wood's light examination, classifying it in four major clinical types and patterns: epidermal, dermal, mixed, and indeterminate. Different treatment options are currently available for melasma. The choice of proper treatment should take into account the type of melasma to be treated, the skin complexion of the patient, possible previous treatments, the expectations and compliance of the patient, and the season in which the treatment is started.Dermatologic Clinics 08/2007; 25(3):337-42, viii. DOI:10.1016/j.det.2007.04.006 · 1.43 Impact Factor
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ABSTRACT: Ilaria Ghersetich, Andrea Bassi, Silvia Betti, Piero Campolmi, and Torello Lotti review the literature with regard to treatment options for melasma, as well as offering a scientific background to the condition. Introduction: Melasma is a typical hypermelanosis, and quite a common dermatological skin disease, which involves sun exposed areas of the skin and mostly affects women of reproductive age. Hyperpigmentation is the result of an increase in cutaneous melanin deposition. Method: Different treatment options are currently available for melasma. This article aims to review the literature pertaining to these treatment options to inform evidence-based practice. Discussion: In mixed and epidermal melasma, the increasingly popular combination of chemical peels (especially superficial – 30% salicylic acid and 10% tretinoin mask) with pharmacologic treatment (hydroquinone, azelaic acid, kojic acid) is a good treatment option. In dermal melasma, physical treatments can be considered, such as intense pulsed light therapy (even though only temporary and transient results are achieved in the authors’ experience), or with fractional laser skin resurfacing (fractional photothermolysis), a new approach using vascular lasers for skin rejuvenation. Conclusions: Melasma continues to be a challenge with regard to treatment options. All melasma patients should be made aware that ultraviolet exposure is a significant triggering or aggravating factor in the development of melasma. The choice of treatment in the melasma patient should take into account the type of melasma to be treated, the skin complexion of the patient, and possible previous treatments.07/2011; 1(3). DOI:10.1080/21598908.2011.601578
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ABSTRACT: Melasma is one of the most common and distressing pigmentary disorders presenting to dermatology clinics. The precise cause of melasma remains unknown; however, there are many possible contributing factors. It is notably difficult to treat and has a tendency to relapse. The existing and most tried topical therapy is hydroquinone and the triple combination with tretinoin and corticosteroids, which is considered the gold standard for melasma. Besides that, azelaic acid, kojic acid, arbutin, ascorbic acid, glycolic acid and salicylic peels have also been tried with limited success. However, multiple novel topical agents are being investigated for their potential as hypopigmenting agents with unique mode of action. But, further trials are required to study their efficacy and safety before they can be further recommended. The article highlights these newer formulations and also briefly mentions about the newer chemical peels and the much hyped lasers in treating this difficult and frustrating condition.Indian journal of dermatology, venereology and leprology 07/2012; 78(4):417-28. DOI:10.4103/0378-6323.98071 · 1.33 Impact Factor