Article

Compound heterozygosity in DJ-1 gene non-coding portion related to parkinsonism.

Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, Italy.
Parkinsonism & Related Disorders (Impact Factor: 4.13). 09/2008; 15(4):324-6. DOI: 10.1016/j.parkreldis.2008.07.001
Source: PubMed

ABSTRACT In this study we analysed the DJ-1 gene in 40 sporadic patients with early onset Parkinson's disease and 100 appropriate controls, originated from southern Italy. We identified a single patient with age at onset of 38 years carrying two previously undescribed heterozygous mutations, both located in non-coding regions. The first mutation was a nucleotide change in the promoter region of the gene (g.159C>G) and the second one was an insertion in the intron 4 splice site (IVS4+3insA). In the same patient, genomic rearrangements were excluded. No DJ-1 mutations were found in the remaining parkinsonian patients. Our results support the growing importance of mutations in non-coding portion of human genome, and confirm that alterations in DJ-1 are a cause, even if rare, of early-onset Parkinson's disease.

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