Article

Chen HY, Chung YW, Lin WY, et al. Collagen type 3 alpha 1 polymorphism and risk of pelvic organ prolapse

Graduate Institute of Integrated Medicine, China Medical University Hospital, Taichung, Taiwan.
International Journal of Gynecology & Obstetrics (Impact Factor: 1.56). 09/2008; 103(1):55-8. DOI: 10.1016/j.ijgo.2008.05.031
Source: PubMed

ABSTRACT To investigate whether pelvic organ prolapse (POP) is associated with collagen 3 alpha 1 (COL3A1) polymorphisms and other factors.
A case-control association study was conducted with 84 women affected with POP and 147 controls. The genotypes of nucleotides COL3A1 rs1800255 and COL3A1 rs1801184 polymorphisms were ascertained by polymerase chain reaction and restriction fragment length polymorphism analysis.
The distribution of the COL3A1 rs1800255 genotypes was significantly different among affected women and controls. Older age and incidence of COL3A1 rs1800255 genotype AA were significantly associated with risk of POP.
There may be an association between COL3A1 genotype and risk of POP.

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    • "However, not all studies find the same associations. Jeon et al. [40] found that the GG genotype of the collagen, type III , alpha 1 (COL3A1) polymorphism was significantly more prevalent among Korean women with POP, whereas both Kluivers et al. [38] and Chen et al. [39] concluded that the AA genotype was significantly associated with POP in Caucasian and Taiwanese females, respectively. On the other hand, Martins et al. [41] found no correlation between the COL3A1 polymorphism and POP in their population. "
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