Myxoid chondrosarcoma of the cricoid cartilage

Department of Pathology, School of Medicine, University of Rijeka, Brace Branchetta 20, Rijeka, Croatia, .
Indian Journal of Pathology and Microbiology (Impact Factor: 0.47). 07/2012; 55(3):424-6. DOI: 10.4103/0377-4929.101772
Source: PubMed
12 Reads
  • Ear, nose, & throat journal 10/2004; 83(9):609. DOI:10.1097/00000478-200207000-00002 · 1.00 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Chondrosarcoma of the head and neck is a rare tumor. In an attempt to clarify optimal treatment of these lesions, we reviewed the records and pathologic material of 18 consecutive cases of head and neck chondrosarcoma seen at our institution between 1955 and 1988. Follow-up ranged from 3 to 168 months with a median of 72. Absolute 5-year survival was 68% (11/16), with 9/16 (56%) patients surviving disease-free. Grade was the most important prognostic factor. Only one of 7 (14%) patients known to have high grade histology was rendered disease-free, as opposed to 9/10 (90%) with low-grade lesions. Tumor size and completeness of surgical resection were also important prognostic factors. Four of 10 patients managed initially with surgery alone achieved local control with greater than 5-year survival. All four had low-grade lesions. Five patients received surgery and radiation as primary treatment, and three are disease-free with greater than 5-year follow-up. Two of these were irradiated because of positive margins. One patient received radiation alone and has persistent disease. Two patients received combined chemotherapy and surgery because of high-grade lesions, and one is free of disease with greater than 5-year follow-up. Patients with incomplete resections should receive further surgery or postoperative radiation therapy. High-grade lesions should be treated aggressively.
    American Journal of Clinical Oncology 06/1993; 16(3):232-237. DOI:10.1097/00000421-199306000-00008 · 3.06 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: BACKGROUND Experience in the treatment of laryngeal chondrosarcoma is based on about 250 cases reported to date. The standard therapy is conservative surgery. Radiotherapy has universally been regarded as ineffective in the treatment of this disease.METHODSA patient with a laryngeal chondrosarcoma was observed for 11 years after radical radiotherapy. The literature on laryngeal chondrosarcoma was critically reviewed, with emphasis placed on radiotherapy.RESULTSThe review of the literature revealed that experience with radiotherapy of laryngeal chondrosarcoma has been lacking, with fewer than 10 cases with short follow-up documented up to now. Meanwhile, increasing evidence of the efficacy of radiotherapy in the treatment of skeletal chondrosarcoma has emerged. The authors report the first case of chondrosarcoma of the larynx in which radical radiotherapy resulted in a long term remission of more than 10 years.CONCLUSIONS Radiotherapy should be considered when radical surgery is not feasible without severe mutilation. It should also be considered for the treatment of residual disease. Laryngectomy should be restricted to salvage treatment when radiotherapy fails. In this study, radiotherapy appeared to be an effective modality in the treatment of low grade laryngeal chondrosarcoma, and these results contrast with the current widespread disapproval of this treatment. Cancer 1998;82: 108-15. © 1998 American Cancer Society.
    Cancer 01/1998; 82(1):108 - 115. DOI:10.1002/(SICI)1097-0142(19980101)82:1<108::AID-CNCR13>3.0.CO;2-6 · 4.89 Impact Factor