Prospective comparison of sorafenib and sunitinib for second-line treatment of cytokine-refractory kidney cancer patients.
ABSTRACT It was the aim of this study to investigate the clinical differences between the tyrosine kinase inhibitors (TKIs) sorafenib and sunitinib as second-line treatment for cytokine-refractory kidney cancer patients.
Twenty consecutive patients received continuous treatment of oral sorafenib at a dose of 400 mg twice daily in 6-week cycles. Sunitinib was administered to the remaining 20 patients at 50 mg once daily in repeated 6-week cycles consisting of daily therapy for 4 weeks, followed by a 2-week off-treatment period. We correlated best treatment responses and progression-free survival (PFS) with either TKI treatment. Adverse events were evaluated and differences were compared between both treatment groups.
In the sorafenib group, 2 (10%) patients showed a partial response (PR) and 4 (20%) patients had progressive disease (PD) versus 6 (30%) PRs and 3 (15%) PDs in the sunitinib group, respectively (p = 0.195). The median PFS was 6.4 months for sorafenib and 7.4 months for sunitinib (p = 0.969). In contrast to gender, age and the number of prior cytokine therapy cycles, the Eastern Cooperative Oncology Group performance status (p = 0.024) and the Memorial Sloan-Kettering Cancer Center risk groups for second-line treatments (p = 0.015) were independent predictive parameters of PFS. Gastrointestinal symptoms were found to occur with greater frequency in the sunitinib group (p = 0.03).
Both TKIs showed comparable clinical benefits. The Eastern Cooperative Oncology Group performance status and the Memorial Sloan-Kettering Cancer Center risk groups can help determine which patients might benefit from alternative drug treatments.
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ABSTRACT: The estimation of the time-varying IF Ω(t) and amplitude A(t) of harmonic signals is considered. The nonparametric local polynomial approximation (LPA) is used in order to develop two new estimators, which enable one to estimate Ω(t), Ω<sup>(1) </sup>(t), ..., Ω((m<sub>ω</sub>-1))(t) and A(t), A<sup>(1) </sup>(t), ..., A((m<sub>A</sub>))(t), where m<sub>ω</sub> and m <sub>A</sub> are the degrees of the LPA of the phase and the amplitude. The a priori amplitude information about Ω(t), A(t) and their derivatives can be incorporated in order to improve the estimates. The estimators of the IF and the amplitude have forms of generalized periodograms and Fourier transforms respectively, where a polynomial function appears in the degree of the complex exponent usual for the Fourier transform. The asymptotic bias and covariance are obtained for the new estimators. In particular, it is shown that one of the new estimators ensures complete compensation of the disturbing influence of the time-varying amplitude for the estimation of the IF and vice versaAcoustics, Speech, and Signal Processing, 1996. ICASSP-96. Conference Proceedings., 1996 IEEE International Conference on; 06/1996
Conference Paper: Compact VLF antenna surrounded with a magnetized plasma shell[Show abstract] [Hide abstract]
ABSTRACT: Summary form only given. Experimental investigations of an electric dipole surrounded with a magnetized plasma shell show that the antenna system can be matched with a feeding line in a wide frequency range near the lower-hybrid frequency. As a result, in the presence of the plasma shell the power radiated by the antenna grew by almost three orders as compared to radiation of the dipole without plasma. It has been shown that the input antenna reactance vanishes to zero at some resonant density of the plasma shell. The antenna has an inductive input reactance at higher plasma densities and a capacitive reactance at lower densities. The field structure inside the plasma shell and in the near zone of the antenna has been extensively investigated. It has been shown that the antenna radiates both as electric and magnetic dipoles. Nonlinear effects in the plasma shell have been studied. It is shown that when increasing the high-frequency power the matching is shifted in dense plasma. The experimental results have been qualitatively interpreted in the framework of an idealized model of the slow mode of a magnetized plasma cylinder. The obtained experimental results are promising for making compact low frequency antennasApplied Electromagnetism, 2000. Proceedings of the Second International Symposium of Trans Black Sea Region on; 02/2000
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ABSTRACT: The past 5 years were marked by fundamental changes in the systemic therapy of metastatic renal cell carcinoma. Up to the end of the last decade cytokine-based chemotherapy was the only, even if only moderately effective systemic therapy for metastatic renal cell carcinoma. Currently there are five new approved drug releases of so-called targeted substances, which function on a molecular based therapeutic mechanism. Sunitinib (Sutent) and sorafenib (Nexavar) as multikinase inhibitors, everolimus (Afinitor) and temsirolimus (Torisel) as mTOR inhibitors, and bevacizumab as an antibody against VEGF in combination with interferon-alpha (IFN-alpha). The following article will give an overview of the currently available substances and critically discuss therapy plans and future trends.Der Urologe 09/2009; 48(9):983-4, 986, 988-9. · 0.44 Impact Factor