Article

Formulation and evaluation of dextromethorphan hydrobromide sustained release tablets.

Department of Pharmaceutical Analysis, JSS College of Pharmacy, Rocklands, Ootacamund-643 001, India.
Drug Delivery (impact factor: 1.46). 10/2008; 15(7):429-35. DOI:10.1080/10717540802035301 pp.429-35
Source: PubMed

ABSTRACT Sustained release (SR) matrix tablets of dextromethorphan hydrobromide were prepared by wet granulation using hydroxypropyl methyl cellulose (HPMC-K-100 CR) as the hydrophilic rate controlling polymer. The effect of the concentration of the polymer and different fillers on the in vitro drug release rate was studied. The studies indicated that the drug release can be modulated by varying the concentration of the polymer and the fillers. A complete cross-over bioavailability study of the optimized formulation of the developed sustained tablets and marketed immediate release tablets was performed on six healthy male volunteers. The extent of absorption of drug from the SR tablets was significantly higher than that for the marketed dextromethorphan hydrobromide tablet because of lower elimination rate and longer half-life.

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    Article: Formulation of Sustained-release diltiazem matrix tablets using hydrophilic gum blends
    Afrasim Moin, H.G. Shivakumar
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    ABSTRACT: Purpose: To develop sustained release matrix tablets of diltiazem hydrochloride (DTZ) using karaya gum (K) alone or in combination with locust bean gum (LB) and hydroxypropyl methylcellulose (H). Methods: Matrix tablets of DTZ were prepared at different ratios of drug:gum (1:1, 1:2, and 1:4) and of the gum blends (K, K/LB, K/H and K/LB/H) by direct compression. The matrix tablets were evaluated for hardness, friability, in vitro release and drug content. The formulations were also characterised by scanning electron microscopy (SEM), Fourier transform infra-red spectroscopy (FTIR) and differential scanning calorimetry (DSC). A commercial diltiazem hydrochloride product Dilzem SR, was used as a reference for comparison. Results: Tablets with only K or K/H had the highest mean dissolution time (MDT), the least dissolution efficiency (DE, 12 %), and released drug by swelling, diffusion and erosion mechanisms. Karaya gum or combinations with locust bean gum sufficiently controlled drug release, while combinations of KH and KLBH exhibited high and low drug release efficiency, respectively. SEM images of the tablets before and after dissolution showed morphological changes on the tablet surface while FTIR and DSC studies indicate that there was no chemical interaction between the drug and the polymers. Three of the formulations compared well with the reference (p < 0.05) in terms of release characteristics. Conclusion: The results of the study demonstrate that karaya gum alone or in suitable combination with locust bean gum and hydroxypropyl methylcellulose is suitable for formulating sustained-release matrix tablets of diltiazem.
    Tropical Journal of Pharmaceutical Research (ISSN: 1596-5996) Vol 9 Num 3.
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Keywords

complete cross-over bioavailability study
 
dextromethorphan hydrobromide
 
different fillers
 
drug release
 
fillers
 
half-life
 
healthy male volunteers
 
HPMC-K-100 CR
 
hydrophilic rate
 
immediate release tablets
 
marketed dextromethorphan hydrobromide tablet
 
optimized formulation
 
SR
 
SR tablets
 
Sustained release
 
tablets
 
vitro drug release rate
 
wet granulation