Liver/spleen volume ratio as a predictor of prognosis in primary biliary cirrhosis.

Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, 791-0295, Japan.
Journal of Gastroenterology (Impact Factor: 4.02). 02/2008; 43(8):632-6. DOI: 10.1007/s00535-008-2202-9
Source: PubMed

ABSTRACT The course of primary biliary cirrhosis (PBC) is determined by clinical symptoms and histological findings. The present study examined the prognostic importance of imaging parameters in PBC.
The volumes of the liver and spleen of patients with PBC were assessed by computed tomography (CT). The volume ratio of liver to spleen (LV/SV ratio) was evaluated and used for further analyses.
The prognosis was significantly poorer in PBC patients with a low, rather than high, LV/SV ratio. The Cox proportional hazard regression model showed that the serum bilirubin level and the LV/SV ratio could predict the prognosis of PBC patients. In addition, the LV/SV ratio was significantly lower in patients who developed symptoms (s-PBC) than in those who remained asymptomatic (a-PBC) during the observation period.
The LV/SV ratio is of prognostic importance in patients with PBC.

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