Article

Alcohol and breast cancer risk defined by estrogen and progesterone receptor status: a case-control study.

Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa, 19-20156 Milan, Italy.
Cancer Epidemiology Biomarkers &amp Prevention (impact factor: 4.12). 08/2008; 17(8):2025-8. DOI:10.1158/1055-9965.EPI-08-0157 pp.2025-8
Source: PubMed

ABSTRACT Alcohol consumption increases breast cancer risk. Some studies suggested that this association is stronger or limited to tumors expressing estrogen receptors (ER).
We investigated the role of alcohol according to ER and progesterone receptor (PR) status in a case-control study on breast cancer conducted from 1991 to 1994 in three Italian areas. Cases were 989 women with incident, histologically confirmed breast cancer. Controls were 1,350 women admitted to hospitals in the same catchment areas for acute nonneoplastic diseases. A validated food-frequency questionnaire was used to collect information on dietary habits and lifetime consumption of various alcoholic beverages. Multiple logistic regression models were used to estimate odds ratios and 95% confidence interval (95% CI).
Alcohol drinking was associated with ER+ tumors (odds ratio, 2.16; 95% CI, 1.68-2.76 for an intake of > or =13.8 g/d as compared with nondrinkers). The odds ratio was 1.13 (95% CI, 1.07-1.20) for a 10-g increase in daily intake. For ER- tumors, the relation with alcohol consumption was not significant (odds ratio, 1.36; 95% CI, 0.93-2.01). When breast cancers were further classified according to PR, the findings for ER+PR+ cancers were similar to those for all ER+ ones, with an odds ratio of 2.34 (95% CI, 1.81-3.04) for an intake of > or =13.8 g/d. No significant association emerged for ER-PR- tumors (odds ratio, 1.25; 95% CI, 0.81-1.94).
This study supports the hypothesis that alcohol is more strongly related to ER+ than to ER- breast tumors.

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    Article: [Risk and protective factors for breast cancer: a systematic review].
    Lívia Emi Inumaru, Erika Aparecida da Silveira, Maria Margareth Veloso Naves
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    ABSTRACT: This review aimed to investigate risk and protective factors for breast cancer and to analyze whether scientific evidence from the World Cancer Research Fund and American Institute for Cancer Research, published in 2007, was confirmed by new research. In May 2010 we reviewed cohort and case-control analytical studies from 2007 to 2010 in the PubMed, LILACS, and SciELO databases. We selected 27 articles (14 case-control and 13 cohort studies). Breastfeeding and physical activity were protective factors against breast cancer, and alcohol consumption was a risk factor. A direct proportional relationship was observed between larger waist circumference, weight throughout adulthood, and height and risk of breast cancer in postmenopausal women. The association between body fat and breast cancer is contradictory in both premenopausal and postmenopausal women. According to the accumulated evidence, breastfeeding and healthy lifestyle are the factors most strongly associated with breast cancer prevention.
    Cadernos de saúde pública / Ministério da Saúde, Fundação Oswaldo Cruz, Escola Nacional de Saúde Pública 07/2011; 27(7):1259-70. · 0.83 Impact Factor
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

10-g increase
 
95% confidence interval
 
acute nonneoplastic diseases
 
Alcohol consumption increases breast cancer risk
 
breast cancers
 
case-control study
 
catchment areas
 
dietary habits
 
ER+PR+ cancers
 
ER- breast tumors
 
ER- tumors
 
ER-PR- tumors
 
estimate odds ratios
 
estrogen receptors
 
Italian areas
 
Multiple logistic regression models
 
progesterone receptor
 
significant association
 
validated food-frequency questionnaire
 
various alcoholic beverages