Split-skin graft in the management of diabetic foot ulcers.
ABSTRACT To compare the effects of split-thickness skin grafts versus a conservative wound dressing on the healing times of diabetic foot ulcers and the length of hospital stay.
In this prospective case-controlled study, 50 patients consented to skin grafting (graft group) and 50 preferred to be managed by conservative dressings (control group). Wound management in both groups was standardised with regard to the dressing materials (which comprised a multilayer dressing including paraffin gauze and diluted povidone-iodine soaked gauze), wound care and surgeon involvement. Graft take, ulcer recurrence rate and donor-site morbidity were assessed. Healing times and the length of hospital stay were compared between the two groups.
A 100% skin graft take was recorded in 84% of the patients on the fifth postoperative day and in 62% on weeks 3 and 8. All patients in the graft group healed completely, but 8% had an ulcer recurrence and 4% a superficial infection within the following year. The mean healing time and mean length of hospital stay were significantly less in the graft group compared with the control group (p<0.001), reflecting results of similar studies.
Split-skin grafting is an effective method of managing diabetic foot ulcers as, compared with the conservative dressings used in this study, it reduced healing times and the length of hospital stay, while donor-site morbidity was minimal.
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ABSTRACT: Impaired wound healing is a frequent and very severe problem in patients with diabetes mellitus, yet little is known about the underlying pathomechanisms. In this paper we review the biology of wound healing with particular attention to the pathophysiology of chronic wounds in diabetic patients. The standard treatment of diabetic ulcers includes measures to optimize glycemic control as well as extensive debridement, infection elimination by antibiotic therapy based on wound pathogen cultures, the use of moisture dressings, and offloading high pressure from the wound bed. In this paper we discuss novel adjuvant therapies with particular reference to the use of autologous skin transplants for the treatment of diabetic foot ulcers which do not respond to standard care.BioMed research international. 01/2013; 2013:385641.
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ABSTRACT: Skin grafts are commonly used to promote healing of shallow wounds and burns, and wound care nurses play an important role in management of wounds treated with grafting. The purpose of this article was to review recent findings regarding strategies to promote healing of split-thickness skin grafts including topical phenytoin or platelet-rich plasma prior to graft application, fibrin sealant, or negative pressure wound therapy to stabilize a graft and to promote close adherence of the graft to the underlying wound bed and adjunctive therapies such as laser.07/2014; 41(4):335-9.
Chapter: Diabetic Foot ulcerGangrene Management-New Advancements and Current Trends, 1st edited by Vitin A., 04/2013: chapter Diabetic Foot Ulcer: pages 47; InTech., ISBN: 978-953-51-1061-3