Article

Regulation of B cell proliferation and differentiation by retinoic acid.

Department of Biochemistry, Institute of Basic Medical Sciences, University of Oslo, PO Box 1112, Blindern, N-0317 Oslo, Norway.
Seminars in Immunology (impact factor: 6.39). 09/2008; 21(1):36-41. DOI:10.1016/j.smim.2008.06.005 pp.36-41
Source: PubMed

ABSTRACT Vitamin A protects against development of infectious diseases, and B cells are important players in this process. Keys to the protective role of retinoic acid (RA) against infections appear to be its ability to enhance antibody responses against T-cell dependent and independent type 2 antigens, as well as to locally stimulate IgA production in mucosal tissues. The elucidation of molecular mechanisms involved in RA-mediated regulation of proliferation and differentiation of B cells not only helps us to understand how RA differentially regulates subsets of B cells, but might also lead to more targeted treatment of selected immune disorders and B cell malignancies.

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Keywords

antibody responses
 
B cell malignancies
 
B cells
 
elucidation
 
independent type 2 antigens
 
molecular mechanisms
 
players
 
proliferation
 
protective role
 
RA
 
RA differentially regulates subsets
 
RA-mediated regulation
 
stimulate IgA production