This paper presents an inkjet printing method for the fabrication of entire microfluidic multianalyte chemical sensing devices made from paper suitable for quantitative analysis, requiring only a single printing apparatus. An inkjet printing device is used for the fabrication of three-dimensional hydrophilic microfluidic patterns (550-mum-wide flow channels) and sensing areas (1.5 mm x 1.5 mm squares) on filter paper, by inkjet etching, and thereby locally dissolving a hydrophobic poly(styrene) layer obtained by soaking of the filter paper in a 1 wt % solution of poly(styrene) in toluene. In a second step, the same inkjet printing device is used to print "chemical sensing inks", comprising the necessary reagents for colorimetric analytical assays, into well-defined areas of the patterned microfluidic paper devices. The arrangement of the patterns, printed inks, and sensing areas was optimized to obtain homogeneous color responses. The results are "all-inkjet-printed" chemical sensing devices for the simultaneous determination of pH, total protein, and glucose in clinically relevant concentration ranges for urine analysis (0.46-46 muM for human serum albumin, 2.8-28.0 mM for glucose, and pH 5-9). Quantitative data are obtained by digital color analysis in the L*a*b* color space by means of a color scanner and a simple computer program.
"In addition, inkjet-printed electronics can be easily bonded with microÀuidic channels using appropriate inkjet printable materials such as SU-8. Inkjet-printed microÀuidic papers have been introduced for chemical sensing and diagnosing applications , . Chemical or biochemical sensors have been realized by using capacitive electrodes. "
[Show abstract][Hide abstract] ABSTRACT: In this letter, a novel fluid-reconfigurable advanced and delayed phase line using a microfluidic composite right/left-handed (CRLH) transmission line (TL) is proposed. A CRLH-TL prototype is inkjet-printed on a photo-paper substrate. In addition, a laser-etched microfluidic channel in poly(methyl methacrylate) (PMMA) is integrated with the CRLH TL using inkjet-printed SU-8 as a bonding material. The proposed TL provides excellent phase-tuning capability that is dependent on the fluidic materials used. As the fluid is changed, the proposed TL can have negative-, zero-, and positive-phase characteristics at 900 MHz for different fluids. The performance of the TL is successfully validated using simulation and measurement results.
"The color changes in the chemical sensing areas have been monitored by the naked eye and measured digitally with specific software after recording a color scan. The patterned paper fabricated by photolithography has been reproduced for biological assays by adding appropriate reagents to the testing areas  . "
[Show abstract][Hide abstract] ABSTRACT: A novel textile-based analytical device with a simultaneous, rapid, sensitive and qualitative response for analyte detection that may have a potential use in different body fluids such as sweat, blood, saliva and urine is proposed in this study as an alternative to its paper-based counterparts. A porous polypropylene spunbond nonwoven was used as base fabric which is superior to paper with higher tear and crinkle resistance, flexibility and wearability.
"dependence on sophisticated clinical infrastructure, long turnaround time and relatively high costs. To invent new technologies suitable for use at the point of care and/or in resource limited settings, microfluidic paper-based analytical devices (µPADs) have emerged as powerful diagnostic tools by virtue of their low cost, portability and ease of operation     . MicroPADs comprise single or multiple layers of paper substrates with hydrophilic paper channels patterned by hydrophobic materials, and can transport fluids autonomously for performing single-or multi-step analytical assays and quantifying concentrations of various analytes in human fluids (e.g. "
[Show abstract][Hide abstract] ABSTRACT: Paper-based microfluidic devices have emerged as simple yet powerful
platforms for performing low-cost analytical tests. This paper reports a
microfluidic paper-based electrochemical biosensor array for multiplexed
detection of physiologically relevant metabolic biomarkers. Different
from existing paper-based electrochemical devices, our device includes
an array of eight electrochemical sensors and utilizes a handheld
custom-made electrochemical reader (potentiostat) for signal readout.
The biosensor array can detect several analytes in a sample solution and
produce multiple measurements for each analyte from a single run. Using
the device, we demonstrate simultaneous detection of glucose, lactate
and uric acid in urine, with analytical performance comparable to that
of the existing commercial and paper-based platforms. The paper-based
biosensor array and its electrochemical reader will enable the
acquisition of high-density, statistically meaningful diagnostic
information at the point of care in a rapid and cost-efficient way.
Science and Technology of Advanced Materials 10/2013; 14(5):4402-. DOI:10.1088/1468-6996/14/5/054402 · 3.51 Impact Factor
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