Article

Comparative genome hybridization array analysis for sporadic Parkinson's disease.

Department of Neurology, The Catholic University of Korea, Seoul, Republic of Korea.
The International journal of neuroscience (impact factor: 0.86). 10/2008; 118(9):1331-45. DOI:10.1080/00207450802174522
Source: PubMed

ABSTRACT Parkinson disease (PD) is a common neurodegenerative disorder, characterized by the loss of midbrain dopamine neurons and Lewy body inclusions. We investigated array CGH to analyze gain or loss of genetic material from 30 patients with PD. We identified the frequent copy number variations in PD; gains in 1p21.1, 4p15.31, 5p15.33, 6q24.1, 7q35, 8q24.3, 10q26.3, 11p15.5-15.4, 12q21.2, 16p13.3, 18q12.3 and 22q13.31, and losses in 1p36.33, and 5q13.2. These findings enable a better description of genetic variations in PD, and could provide a foundation for understanding the critical regions of the genome that may be involved in the development of PD.

0 0
 · 
0 Bookmarks
 · 
33 Views
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

30 patients
 
array CGH
 
common neurodegenerative disorder
 
critical regions
 
frequent copy number variations
 
genetic material
 
genetic variations
 
Lewy body inclusions
 
midbrain dopamine neurons
 

Joong-Seok Kim