Does tachyphylaxis occur after repeated antidepressant exposure in patients with Bipolar II major depressive episode?

Depression Research Unit, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-3309, United States.
Journal of Affective Disorders (Impact Factor: 3.38). 08/2008; 115(1-2):234-40. DOI: 10.1016/j.jad.2008.07.007
Source: PubMed


Tachyphylaxis often refers to the loss of antidepressant efficacy during long-term treatment. However, it may also refer to the gradual loss of efficacy after repeated antidepressant exposures over time. The aim of this study was to examine the phenomenon of tachyphylaxis in patients with Bipolar II major depression treated with either venlafaxine or lithium. We hypothesized that a greater number of prior antidepressant exposures would result in a reduced response to venlafaxine, but not lithium, therapy.

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    • "A study on antidepressant-associated chronic irritable dysphoria (ACID) showed that it was significantly more common among bipolar I and II depressives who received antidepressants than among those who did not receive antidepressants, and the development of ACID (i.e., worsening of depression) was significantly related to past history of antidepressant-induced mood switches [14]. It is also known that bipolar spectrum and bipolar II depressives have frequently a loss of response to repeated trials of antidepressants (also called as tachyphyaxis) before developing chronic and severe AD-RD [8, 21]. "
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    ABSTRACT: The complex relationship between the use of antidepressants and suicidal behaviour is one of the hottest topics of our contemporary psychiatry. Based on the literature, this paper summarizes the author's view on antidepressant-resistant depression and antidepressant-associated suicidal behaviour. Antidepressant-resistance, antidepressant-induced worsening of depression, antidepressant-associated (hypo)manic switches, mixed depressive episode, and antidepressant-associated suicidality among depressed patients are relatively most frequent in bipolar/bipolar spectrum depression and in children and adolescents. As early age at onset of major depressive episode and mixed depression are powerful clinical markers of bipolarity and the manic component of bipolar disorder (and possible its biological background) shows a declining tendency with age antidepressant-resistance/worsening, antidepressant-induced (hypo)manic switches and "suicide-inducing" potential of antidepressants seem to be related to the underlying bipolarity.
    Depression research and treatment 04/2011; 2011(2090-1321):906462. DOI:10.1155/2011/906462
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    ABSTRACT: Tachyphylaxis is the appearance of progressive decrease in response to a given dose after repetitive administration of a pharmacologically or physiologically active substance; the symptoms could appear also during treatment with antidepressants. Although the real frequency of the phenomenon is unclear, it may be as high as 33% during the pharmacological treatment of depression. The review deals with the possible causes and the treatment of the tachyphylaxis following antidepressant treatment.
    The Israel journal of psychiatry and related sciences 01/2011; 48(2):129-35. · 0.79 Impact Factor
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    ABSTRACT: En el 2004 fue publicada una revisión detallada sobre las características terapéuticas de los medicamentos utilizados en el tratamiento de los trastornos bipolares [Tamayo JM et al. Actas Esp Psiquiatr 2004;32(Supl. 1):3-17]. En aquél momento se podía concluir que si bien los eutimizantes compartían algunos mecanismos de acción, eran a la vez sustancialmente diferentes respecto a sus propiedades terapéuticas en las diferentes fases de los trastornos bipolares llevando a proponer un cambio en su clasificación genérica como �estabilizadores del estado de ánimo� a una nueva incluyendo: antimaníacos, estabilizadores parciales del ánimo y eutimizantes. Desde entonces, han sido publicados varios estudios doble-ciego aleatorizados y meta-análisis, explorando la eficacia y tolerabilidad de estos medicamentos. Esta revisión actualizada pretende evaluar, a la luz de la nueva evidencia, la validez de la propuesta de clasificación publicada en ese entonces.
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