Syndecan 1 (CD138) serum levels: a novel biomarker in predicting liver fibrosis stage in patients with hepatitis C

Gastroenterology Institute and Liver Unit, Tel Aviv Sourasky Medical Center, Weizmann 6, Tel Aviv, Israel.
Liver international: official journal of the International Association for the Study of the Liver (Impact Factor: 4.85). 09/2008; 29(2):208-12. DOI: 10.1111/j.1478-3231.2008.01830.x
Source: PubMed


Syndecan 1 (CD 138) is a cell surface proteoglycan shed by cells in several pathological conditions, including wound healing. The aim of this study was to test whether CD138 could serve as a non-invasive marker for detection of liver fibrosis and thereby reduce the need for liver biopsy.
An estimation set of 134 patients and a validation set of 67 patients with chronic hepatitis C were studied. There were 80 normal healthy volunteers. Patients were staged according to liver biopsies (Metavir fibrosis staging, stage F0, n=35; F1, n=40; F2, n=37, F3, n=39; F4, n=51). Serum CD138 levels were retrospectively measured by enzyme-linked immunoabsorbent assay the same day of the liver biopsy. The primary endpoints were the diagnostic values of CD138 for F2-F4, F3-F4 and F4.
Respective areas under receiver operating characteristic curve of CD138 for F2-F4, F3-F4 and F4 diagnosis were 0.82, 0.76 and 0.81. CD138 had a positive predictive value of 82% for F2-F4 diagnosis and a high negative predictive value (86%) and specificity (84%) for exclusion of F4.
CD138 is a new simple non-invasive marker for predicting liver fibrosis in patients with chronic hepatitis C. The relevance of this marker in combination with other fibrosis markers should be explored.

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    • "Soluble syndecan-1 and -4 ectodomains are detected in inflamed or infected body fluids, indicating a physiological role for shedding in diseases (Subramanian et al. 1997; Wang et al. 2008; Zvibel et al. 2009). Syndecan ectodomains are replete with all of their HS chains and are thought to maintain their ability to interact with the same ligands as the cell surface syndecans, and thus act as soluble autocrine or paracrine effectors. "
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