Article

Are CD57+ natural killer cells really important in early pregnancy failure?

Department of Obstetrics and Gynecology, Baskent University Faculty of Medicine, Ankara, Turkey.
Archives of Gynecology (Impact Factor: 0.91). 09/2008; 279(4):493-7. DOI: 10.1007/s00404-008-0736-y
Source: PubMed

ABSTRACT The aim of this study was to compare the CD57+ Natural Killer (NK) cell counts in normal pregnancies and in cases grouped according to different types of early pregnancy failure.
A prospective case control study which was set in Baskent University Faculty of Medicine, Obstetrics and Gynecology Department. A total of 119 women whose pregnancies ended in the first trimester were divided into elective pregnancy termination, incomplete miscarriage, intrauterine demise, ectopic pregnancy and recurrent pregnancy loss groups. CD57+ NK cells were stained and counted in the histologic preparations of the decidua in all of these groups.
CD57+ NK cell counts were 2.14+/-1.42 in control, 2.24+/-1.92 in incomplete miscarriage, 1.82+/-1.34 in intrauterine demise, 2.54+/-1.80 in ectopic pregnancy and 3.42+/-2.15 in recurrent pregnancy failure group. There were no statistically significant differences between the control group and the other four groups with respect to the CD57+ NK cell counts.
This study suggests that CD57+ NK cell count is not associated with early pregnancy failure.

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